Antiproliferative Effects of the Traditional Chinese Medicine Shimotsu-To, Its Component Cnidium Rhizome and Derived Compounds on Primary Cultures of Mouse Aorta Smooth Muscle Cells.
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概要
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Antiproliferative effects of the Japanese-Sino medicine <I>Shimotsu-to</I> (a combined prescription of cnidium rhizome, angelica root, peony root and rehmannia root) were investigated in the primary culture of smooth muscle cells (SMC) of mouse aorta. Fetal bovine serum (10%)-induced proliferation of primary cultured SMC was inhibited by <I>Shimotsu-to</I> at 4, 20, 100 or 500 μg/ml. The inhibitory effect was selective on SMC and due to cnidium rhizome or angelica root. The IC<SUB>50</SUB> values of senkyunolide H, senkyunolide A, ligustilide and butylidenephthalide derived from cnidium were below 0.1, 1.52, 1.68 and 3.25 μg/ml, respectively. These results indicate that the antiproliferative effect of <I>Shimotsu-to</I> may depend on these cnidium-derived phthalides.
著者
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Kobayashi Shinjiro
Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Mimura Yasuhiko
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Notoya Kouhei
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Kobayashi Shinjiro
Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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