INHIBITORY EFFECT OF MOLECULAR MOIETY IN PAPAVERINE STRUCTURE ON CYCLIC AMP-PHOSPHODIESTERASE OF SMOOTH AND CARDIAC MUSCLES
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概要
- 論文の詳細を見る
Inhibitory effects on low Km cyclic AMP-phosphodiesterase (PDE) obtained from guinea-pig ileum and rat cardiac muscle were studied using papaverine (Pap) and its related moiety compounds which were classified into group I : isoquinoline derivatives, group II : 2-veratrylpyridine derivatives and group III : 1-veratryl-veratrylamine derivatives. 3,4-Dimethyl-2-veratryl-pyridine (P-3,4M) belonging to group II was more effective than 1-methyl-6,7-dimethoxy-isoquinoline (IQ) belonging to group I, but not so as Pap. Compounds in group III were little effective inhibitors. Pap and P-3,4M seemed to be a competitive type and IQ to be a non-competitive type of compound. In the steric configuration of Pap molecule, an aphorphine type compound was more effective than a berberine type compound. Barium chloride did not exert any antagonistic effect upon low Km cyclic AMP-PDE inhibited by Pap. Potentiation effects on dose-relaxation curve induced by cyclic AMP in guinea-pig taenia coli fell into the order of Pap>P-3,4M>IQ, being parallel with the potency order of cyclic AMP-PDE inhibition.
- 公益社団法人日本薬学会の論文
著者
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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KIMURA Ikuko
Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, Toyama medical and Pharmaceu
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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WAKI ISAMI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Waki Isami
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Waki Isami
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Kimura Masayasu
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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