Effects of Flecainide on the Electrophysiological Properties of Atrial Vulnerability in Humans
スポンサーリンク
概要
- 論文の詳細を見る
The aims of this study were to evaluate the changes in the electrophysiological characteristics of the right atrium after the administration of flecainide and to clarify whether flecainide has a selective effect on human atrial tissue. Electrophysiological measurements were made in 38 patients, before and after intravenous administration of flecainide (2mg/kg per lOmin). The effective refractory period of the right atrium (ERP-A), maximum conduction delay (Max. CD), repetitive atrial firing zone (RAFZ), fragmented atrial activity zone (FAAZ), and conduction delay zone (CDZ) were studied in the patients who were divided into 2 groups based on whether repetitive atrial firing (RAF) was induced in the baseline study. Flecainide significantly prolonged the ERP-A (202±22 to 238±33ms, p<0.001) and shortened Max. CD (77±17 to 63±32ms, p<0.05) in the patients with RAF, but not in those without RAF in the baseline study. After flecainide administration, there were significant reductions in the RAFZ (43±22 to 13±19ms, p<0.0001), FAAZ (51±22 to 28±26ms, p<0.001) and CDZ (70±21 to 48±30ms, p<0.01) in the patients with RAF. However, atrial fibrillation (AF) was induced by stimulation after flecainide in 2 patients without RAF in the baseline study. There was a significant negative correlation between the ERP-A in the baseline study and the change in the ERP-A upon flecainide administration (r=0.45, p<0.01). Flecainide may preferentially activate the substrate for AF and RAF, but that action is mainly based on the electrophysiological characteristics found in the baseline study.
- 社団法人日本循環器学会の論文
- 2003-04-20
著者
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MATSUZAKI Masunori
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Kimura Masayasu
Division of Cardiology, Tokuyama Central Hospital
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Kimura Masayasu
Division Of Cardiology Tokuyama Central Hospital
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Doi Masahiro
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Shimizu Akihiko
Faculty Of Health Sciences Yamaguchi University School Of Medicine
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Ueyama Takeshi
Division of Cardiology, Yamaguchi University Graduated School of Medicine
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Shimizu Akihiko
Division of Cardiology, Yamaguchi University Graduated School of Medicine
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Doi Masahiro
The Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University Graduate School
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Ueyama Tsuyoshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yoshiga Yasuhiro
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Yamagata Toshihiko
Department of Cardiology, Yamaguchi Grand Medical Center
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Esato Masahiro
Division of Cardiovascular Medicine, Department of Medical Bioregulation
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Ohmura Masato
Division of Cardiovascular Medicine, Department of Medical Bioregulation
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Kakugawa Hiroyuki
Department of Cardiology, Yamaguchi University School of Medicine
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Yamagata Toshihiko
Division of Cardiology, Yamaguchi Prefectural Central Hospital
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Kakugawa Hiroyuki
Division of Cardiovascular Medicine, Yamaguchi University School of Medicine
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Itagaki Kazuo
Division of Cardiovascular Medicine,The Department of Medical Bioregulation,Yamaguchi University Sch
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Kanemoto Masashi
滋賀医科大学 呼吸循環器内科
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Doi Masahiro
Division Of Cardiovascular Medicine The Department Of Medical Bioregulation Yamaguchi University Sch
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Ueyama Takeshi
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Ueyama Takeshi
Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Itagaki Kazuo
Division Of Cardiovascular Medicine The Department Of Medical Bioregulation Yamaguchi University Sch
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Shimizu Akihiko
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
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Doi Masahiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Itagaki Kazuo
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Yoshiga Yasuhiro
Tokyo Metropolitan Government Hiroo General Hospital
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Kakugawa Hiroyuki
Department Of Cardiology Yamaguchi University School Of Medicine
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Yamagata Toshihiko
Department Of Cardiology Yamaguchi Grand Medical Center
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Ohmura Masato
Division Of Cardiovascular Medicine Department Of Medical Bioregulation
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Shimizu Akihiko
Division Of Cardiology And Faculty Of Health Sciences Yamaguchi University Graduate School Of Medici
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Shimizu Akihiko
Department Of Nursing Yamaguchi University School Of Medicine
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Yoshiga Yasuhiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Yoshiga Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Scioence Yamaguchi University Graduate Sc
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Esato Masahiro
Division Of Cardiovascular Medicine Department Of Medical Bioregulation
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Graduate School Of Medicine Yamag
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Shimizu Akihiko
Division Of Cardiology And Faculty Of Health Sciences Yamaguchi University Graduated School Of Medic
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Yoshiga Yasuhiro
Department Of Cardiology Shimane Prefectural Central Hospital
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Shimizu Akihiko
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Doi Masahiro
Division Of Cardiology Kounan St. Hill Hospital
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Yoshiga Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Ueyama Takeshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Doi Masahiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Shimizu Akihiko
Division Of Cardiology And Faculty Of Health Sciences Yamaguchi University Graduate School Of Medici
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Shimizu Akihiko
Faculty Of Health Sience Yamaguchi University Graduated School Of Medicine
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Kimura Masahiro
Division Of Cardiovascular Medicine The Department Of Medical Bioregulation Yamaguchi University Sch
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