Tongue Muscle-Derived Stem Cells Express Connexin 43 and Improve Cardiac Remodeling and Survival After Myocardial Infarction in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Background: Cell transplantation therapy for heart failure is hindered by poor differentiation into cardiomyocytes and arrhythmias caused by the poor expression of connexin 43 (Cx43). A new stem cell source for cardiac regeneration is needed. Methods and Results: Tongue muscle-derived Sca-1(+) cells (TDSCs) were isolated from normal and green fluorescence protein (GFP)-transgenic mouse tongues using surface antigen Sca-1. Cardiomyogenic differentiation was confirmed by measuring the calcium transient and the expression of cardiac-specific genes. The formation of gap junctions was confirmed by the expression of Cx43 and the dye transfer method. The contraction of regenerated cells was demonstrated by the calcium transients. GFP mouse-derived TDSCs were transplanted into hearts in a model of acute myocardial infarction. Three months after transplantation, LV remodeling was attenuated and the survival rate was improved compared with the control group. Conclusions: TDSCs form gap junctions and improve cardiac function and long-term survival after myocardial infarction.
- 2010-05-25
著者
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MATSUZAKI Masunori
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Matsuzaki Masunori
Yamaguchi University Graduate School of Medicine
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Matsuzaki Masunori
富山大学 医学部バイオ統計学臨床疫学
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Ikeda Yasuhiro
山口大学 医学系研究科
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Ikeda Yasuhiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Ikeda Yasuhiro
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Miura Toshiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Miura Toshiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Fukagawa Yasuhiro
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Kawamura Shuji
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Oda Takamasa
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Akashi Shintaro
Division Of Cardiology Tokuyama Central Hospital
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Akashi Shintaro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Shibuya Masaki
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Mitsui M
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Ikeda Yasuhiro
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Matsuoka Mitsuteru
琉球大学医学部 第三内科
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Matsubara Mitsunobu
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Miyahara Mitsuo
The Second Department Of Internal Medicine Sapporo Medical College
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Ikeda Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Ikeda Yasuhiro
山口大学 医学系研究科器官病態内科学
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Fukagawa Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawamura Shuji
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawahara Shinji
Devision Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University School Of Me
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Oda Takamasa
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Akashi Shintaro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Matsuoka M
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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SHIBUYA Masaki
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Shibuya Masaki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Matsuzaki Masunori
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Miura Toshiro
Second Department Of Internal Medicine Yamaguchi University School Of Mediciney
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Matsuzaki M.
Yamaguchi University School of Medicine
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Matsui Toshihiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawahara Shinji
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Miura Toshiro
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Graduate School Of Medicine Yamag
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Motone Masaharu
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Ikeda Yasuhiro
Dept. Of Medical Bioregulation Division Of Cardioventricular Medicine Yamaguchi University School Of
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Mochizuki Mamoru
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Miyahara Mitsuo
Dept. Of Intern. Med. (section 2) Sapporo Med. Coll.
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Mori Masaki
Division Of Gene Therapy Science Osaka University
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Mochizuki Mamoru
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Murakami Masanori
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Matsuzaki Masunori
綜合病院社会保険徳山中央病院 心臓血管外科
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Matsuzaki Masunori
The Second Department Of Internal Medicine University Of Yamaguchi
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Matsuaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Matsuzaki Masunori
Japanese Circulation Society Guideline Preparation Group Myocarditis
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Matsuaki Masunori
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
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Murakami Masanori
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Miyahara Mitsuo
2nd Div. Dept. Of Intern. Med. Sapporo Med. Coll.
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Murakami Masanori
Department Of Surgery And Clinical Science Division Of Cardiac Surgery Yamaguchi University Graduate
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Graduate School Of Medicine Yamag
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Murakami Masanori
The Second Division Of Internal Medicine Yamaguchi University School Of Medicine
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