Beta-Blocker Decreases the Increase in QT Dispersion and Transmural Dispersion of Repolarization Induced by Bepridil
スポンサーリンク
概要
- 論文の詳細を見る
Bepridil is effective for intractable cardiac arrhythmia, but in rare cases will induce torsades de pointes (TdP) associated with QT interval prolongation. Beta-blockers will effectively prevent TdP in some clinical settings, so the effect of ★-blocker on the change in QT interval, QT dispersion and transmural dispersion of repolarization (TDR) induced by bepridil was investigated in 10 patients (7 male, 3 female; 62★6 years old) with intractable paroxysmal atrial fibrillation. The QTc interval, QTc dispersion and TDR were measured before and after 1 month of administration of bepridil, and then a ★-blocker was added and the QTc interval, QTc dispersion and TDR re-measured 1 month later. Bepridil significantly prolonged the QTc interval (0.42★0.05 to 0.50★0.08; p<0.01), and increased both the QT dispersion (0.07★0.05 to 0.14★0.08; p<0.01) and TDR (0.10★0.04 to 0.16★0.05; p<0.01). The addition of a ★-blocker decreased the QTc interval (0.50★0.08 to 0.47★0.04; p=0.09) and significantly decreased both the QTc dispersion (0.14★0.08 to 0.06★0.02; p<0.01) and TDR (0.16★0.05 to 0.11★0.04; p<0.001). Compared with the control, the combination therapy significantly prolonged the QTc interval, but did not increase either QTc dispersion or TDR, and so was effective in all patients with intractable AF. The findings suggest that★-blocker reduces the increase in QT dispersion and TDR induced by bepridil, and combined therapy with bepridil and ★-blocker might thus be useful for intractable atrial fibrillation.
- 社団法人日本循環器学会の論文
- 2002-10-20
著者
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MATSUZAKI Masunori
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Kimura Masayasu
Division of Cardiology, Tokuyama Central Hospital
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Kimura Masayasu
Division Of Cardiology Tokuyama Central Hospital
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Shimizu Akihiko
Faculty of health Sciences, Yamaguchi University School of Medicine
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Shimizu Akihiko
Faculty Of Health Sciences Yamaguchi University School Of Medicine
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Shimizu Akihiko
Faculty Of Health Science Yamaguchi University School Of Medicine
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Ueyama Takeshi
Division of Cardiology, Yamaguchi University Graduated School of Medicine
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Ueyama Tsuyoshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yoshiga Yasuhiro
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Yamagata Toshihiko
Department of Cardiology, Yamaguchi Grand Medical Center
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Ohmura Masato
Division of Cardiovascular Medicine, Department of Medical Bioregulation
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Yamagata Toshihiko
Division of Cardiology, Yamaguchi Prefectural Central Hospital
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Itagaki Kazuo
Division of Cardiovascular Medicine,The Department of Medical Bioregulation,Yamaguchi University Sch
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Hayano Tomoko
Division of Cardiovascular Medicine, Yamaguchi University School of Medicine
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Kanemoto Masashi
滋賀医科大学 呼吸循環器内科
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Itagaki Kazuo
Division Of Cardiovascular Medicine The Department Of Medical Bioregulation Yamaguchi University Sch
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Shimizu Akihiko
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
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Itagaki Kazuo
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Yoshiga Yasuhiro
Tokyo Metropolitan Government Hiroo General Hospital
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Yamagata Toshihiko
Department Of Cardiology Yamaguchi Grand Medical Center
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Ohmura Masato
Division Of Cardiovascular Medicine Department Of Medical Bioregulation
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Yoshiga Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Scioence Yamaguchi University Graduate Sc
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Hayano Tomoko
Division Of Cardiovascular Medicine Yamaguchi University School Of Medicine
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Graduate School Of Medicine Yamag
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Yoshiga Yasuhiro
Department Of Cardiology Shimane Prefectural Central Hospital
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Shimizu Akihiko
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Yoshiga Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Ueyama Takeshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Shimizu Akihiko
Division Of Cardiology And Faculty Of Health Sciences Yamaguchi University Graduate School Of Medici
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Shimizu Akihiko
Faculty Of Health Sience Yamaguchi University Graduated School Of Medicine
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Kimura Masahiro
Division Of Cardiovascular Medicine The Department Of Medical Bioregulation Yamaguchi University Sch
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Shimizu Akihiko
Faculty Of Health Science Yamaguchi University Graduate School Of Medicine
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Shimizu Akihiko
Faculty Of Health Science Yamaguchi University
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