Effects of In Vivo Gene Transfer of Fibroblast Growth Factor-2 on Cardiac Function and Collateral Vessel Formation in the Microembolized Rabbit Heart
スポンサーリンク
概要
- 論文の詳細を見る
The effects of gene transfer of the secreted form of fibroblast growth factor-2 (FGF-2) were tested using an adenovirus vector in the microembolized rabbit heart. Japanese white rabbits underwent an intracoronary injection of 25-μm microspheres followed by recombinant adenovirus vectors encoding a secreted form of FGF-2 (FGF group), LacZ (LacZ group), or saline (saline group). Left ventricular (LV) systolic function was serially assessed by echocardiography. Vascular density was measured at 14 days with Azan and CD31 staining. The development of collateral vessels was assessed by measuring myocardial blood flow before and after the occlusion of the left anterior descending coronary artery. Percent fractional shortening (%FS) decreased after the microembolization, and improved gradually for 14 days in the FGF group only (41±1%(FGF)vs 32±1%(LacZ), 31±1%(saline), p<0.01). The vascular density and myocardial collateral blood flow were significantly higher in the FGF group in comparison with other groups. Transcoronary arterial gene transfer of the secreted form of FGF-2 was beneficial for the recovery of LV systolic function and development of collateral vessels in the microembolized rabbit heart.
- 社団法人日本循環器学会の論文
- 2001-02-20
著者
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MATSUZAKI Masunori
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Kimura Masayasu
Division of Cardiology, Tokuyama Central Hospital
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Miura Toshiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Miura Toshiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Okamura Takayuki
Division of Cardiology,Department of Medicine and Clinical Science,Yamaguchi university Graduate Sch
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Dairaku Yuka
Division of Cardiovascular Medicine, Yamaguchi University School of Medicine
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Kimura Masayasu
綜合病院社会保険徳山中央病院 循環器内科
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Kimura Masayasu
Division Of Cardiology Tokuyama Central Hospital
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Ikeda Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawamura Shuji
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yamaguchi Kazuhito
Institute Of Laboratory Animals Yamaguchi University Graduate School Of Medicine
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Kanemoto Masashi
滋賀医科大学 呼吸循環器内科
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Yamamoto K
Rheumatology Immunology And Genetics Program Institute Of Medical Science St. Marianna University
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Yudoh Kazuo
Department Of Bioregulation And Proteomics Institute Of Medical Science St. Marianna University Scho
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Dairaku Yuka
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
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Dairaku Yuka
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Iwatate Mitsuo
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Iwatate Mitsuo
Division of Cardiovascular Medicine, The Department of Medical Bioregulation
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Ueno Hikaru
The Department of Biochemistry, University of Occupational and Environmental Health
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Yamamoto Takuo
山口大学 循環器内科
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Miura Toshiro
Second Department Of Internal Medicine Yamaguchi University School Of Mediciney
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Okamura Takayuki
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Okamura Takayuki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawahara Shinji
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Dairaku Yuka
山口大学 循環器病態内
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Graduate School Of Medicine Yamag
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Yamamoto Kazuhiko
Departments Of Allergy And Rheumatology University Of Tokyo Graduate School Of Medicine
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Ikeda Yasuhiro
Dept. Of Medical Bioregulation Division Of Cardioventricular Medicine Yamaguchi University School Of
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Miyazaki Tsuyoshi
Department Of Rheumatology Sagamihara National Hospital National Hospital Organization (nho)
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Ueno Hikaru
The Department Of Biochemistry And Molecular Pathophysiology University Of Occupational And Environm
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Ueno Hikaru
The Department Of Biochemistry University Of Occupational And Environmental Health
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Dairaku Yuka
Division Of Cardiovascular Medicine The Department Of Medical Bioregulation Yamaguchi University Sch
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Yamamoto Kazuhiko
Department Of Rheumatology And Applied Immunology Faculty Of Medicine Saitama Medical University Hos
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Okamura Takayuki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yamaguchi Kazuhito
Department Of Bioregulation And Proteomics Institute Of Medical Science St. Marianna University Scho
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Yokota Kazuhiro
Department Of Rheumatology And Applied Immunology Faculty Of Medicine Saitama Medical University Hos
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Yokota Kazuhiro
Department Of Rheumatology And Applied Immunology Faculty Of Medicine Saitama Medical University Hospital
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