Beneficial Effects of the Dual L- and T-Type Ca^<2+> Channel Blocker Efonidipine on Cardiomyopathic Hamsters
スポンサーリンク
概要
- 論文の詳細を見る
Background The T-type Ca^<2+> channel (TCC) is activated, and abnormalities of the TCC may be related to the pathogenesis of Ca^<2+> overload, in cardiomyopathic hamster hearts. The aims of the present study were to investigate the alteration in expression of the TCC and to examine the effects of a dual L- and T-type Ca^<2+> channel blocker, efonidipine (EFO), on cardiac function and TCC during development of heart failure in UM-X7.1 cardiomyopathic hamsters. Methods and Results UM-X7.1 and golden hamsters were examined, and EFO was administered at the age of 20 weeks for 4 weeks. Cardiac function was examined, the expression of TCCα1G was measured, and ventricular myocytes were subjected to a patch-clamp study. At 24 weeks, vehicle-treated UM-X7.1 hamsters exhibited significant increases in left ventricular (LV) size, with marked decreases in ejection fraction (LVEF) compared with golden hamsters. In the UM-X7.1 group, the expression of TCCα1G increased during development of heart failure compared with the golden hamster group. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by〜10%) in both groups. In the golden hamster group, EFO treatment did not affect LV function. The TCC current in ventricular myocytes was significantly increased in UM-X7.1, and was inhibited by EFO in a dose-dependent manner. Conclusions In cardiomyopathic hamster hearts, abnormalities in the TCC may be at least in part related to the pathogenesis of abnormal Ca^<2+> homeostasis, and TCC-blocker treatment may decrease the TCC current, resulting in an improvement of cardiac function. TCC blocker therapy might be a new strategy for certain types of heart failure.
- 社団法人日本循環器学会の論文
- 2007-11-20
著者
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MATSUZAKI Masunori
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Murato Y
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Takahashi Shigezo
Department Of Medicine And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Murata Yoshiharu
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Ohkusa Tomoko
Division of Cardiology, Department of Medicine and Clinical Science,Yamaguchi University Graduate Sc
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Suzuki Shinsuke
Division of Cardiology, Department of Medicine and Clinical Science,Yamaguchi University Graduate Sc
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Saga Sinsuke
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Ohkusa Tomoko
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yano Masafumi
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Yamamoto M
Department Of Cardiology Mitsubishi-nagoya Hospital
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SATO Takashi
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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YANO Masafumi
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Ohkusa Tomoko
Yamaguchi University Graduate School of Medicine
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Yamazaki Masatoshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yamazaki Masatoshi
名古屋大学環境医学研究所 循環器学
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TAKEBAYASHI Satoshi
Department of Cardiovascular Surgery, Oita University, Faculty of Medicine
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Ohkusa Tomoko
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
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Yoshida Masa-aki
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Ono Katsushige
Department of Cardiovascular Science, Oita University School of Medicine
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Murata Yoshiharu
Department Of Civil Engineering College Of Engineering Nihon University
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Murata Y
Department Of Teratology And Genetics Research Institute Of Environmental Medicine Nagoya University
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Yano Masafumi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Murata Yoshiharu
Departments Of Genetics Research Institute Of Environmental Medicine Nagoya University
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Ono Katsushige
Department Of Cardiovascular Science Faculty Of Medical Oita University
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Yamamoto Mariko
名古屋大学環境医学研究所
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Murata Yoshiharu
名古屋大学環境医学研究所 発生･遺伝学
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Yoshiga Masahiko
The Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University Graduate School
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Takebayashi Satoshi
Department Of Cardiovascular Science Oita University School Of Medicine
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Suzuki Shinsuke
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Murata Yoshiharu
Department Of Endocrinology And Metabolism Research Institute Of Environmental Medicine
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Yamazaki Masatoshi
Division Of Cardiology Shizuoka Saiseikai General Hospital
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Yamazaki Masatoshi
Research Institute Of Environmental Medicine Nagoya University
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Graduate School Of Medicine Yamag
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Murata Y
Nagoya Univ. Nagoya‐shi
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Yamamoto Mitsuru
名古屋大学環境医学研究所
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Yano Masafumi
Department Of Cardiovascular Medicine Yamaguchi University School Of Medicine
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Ohkusa Tomoko
The Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Suzuki Shinsuke
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Yamazaki Masatoshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yamamoto Mitsuru
Department Of Circulation Research Institute Of Environmental Medicine Nagoya Unoversity
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Yamamoto Masahiro
Yokohama City Cerebrovascular Center Yokohama Japan
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Susa Takehisa
Department Of Medicine And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Yoshida Masaaki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Matsuzaki Masunori
The Depart. Of Int. Med. Yamaguchi Univers. School Of Med.
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Yoshida Masa-aki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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