Inhibitory Effects of Traditional Chinese Medicine Shimotsu-to and Its Included Crude Fractions on Adjuvant-Induced Chronic Inflammation of Mice
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概要
- 論文の詳細を見る
Effects of a traditional Chinese medicine, Shimotsu-to (a combined prescription of cnidium rhizome, peony root, angelica root and rehmannia root), and its included crude fractions were investigated on an adjuvant-induced chronic inflammation model of mice. The aqueous extract (30,100 and 300 mg/kg, i.p.) of Shimotsu-to reduced the carmine content, granuloma weight, inflammation cell count and pouch fluid weight in the inflammation model, respectively. The extract of Shimotsu-to without cnidium at the same doses did not produce significant changes in these four inflammatory parameters. The same doses of extracts of Shimotsu-to without peony, and without angelica, weakly reduced these parameters, except for pouch fluid weight. The extract (30,100 and 300 mg/kg) of cnidium significantly reduced these four parameters. The same doses of peony extract reduced carmine content, granuloma weight and pouch fluid weight, but less than those of the cnidium extract. The extract of cnidium and peony at the same doses reduced in an additive manner these inflammatory parameters in their combination. These results demonstrated that the Shimotsu-to extract reduced angiogenesis, granuloma formation, inflammatory cell migration and pouch fluid exudation in the adjuvant-induced chronic inflammation model. Cnidium represented the main ingredient for producing the anti-chronic inflammatory effects of Shimotsu-to extract. Cnidium and peony exhibited additive anti-inflammatory effects in combination.
- 社団法人日本薬学会の論文
- 1996-01-15
著者
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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Kimura M
Health Science Center At San Antonio The University Of Texas
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KOBAYASHI Shinjiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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INABA Kazuhiko
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Inaba Kazuhiko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Inaba Kazuhiko
北陸大学 薬 薬理
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KOJIMA Satoru
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Kimura I
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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Kimura M
Tsumura & Co. Ltd. Ibaraki Jpn
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Kimura Masayasu
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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Kimura I
Department Of Ophthalmology Keio University School Of Medicine
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kobayashi Shinjiro
Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University
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Inaba K
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kobayashi S
Kyoritsu Coll. Pharmacy
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Kojima Satoru
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kojima Satoru
Department Of Biosphere Science Faculty Of Science Toyama University
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Kobayashi Shinjiro
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kobayashi Shinjiro
Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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