Pharmacokinetic Interaction of Zonisamide in Rats. Effect of Other Antiepileptics on Zonisamide
スポンサーリンク
概要
- 論文の詳細を見る
The pharmacokinetics of zonisamide (ZNS) and the effects of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) on ZNS kinetics were investigated in rats. The effects of other antiepileptics on the serum protein binding, erythrocyte distribution and metabolism of ZNS were also studied in vitro to elucidate the mechanism of pharmacokinetic interaction of ZNS. ZNS showed a linear disposition kinetics after oral administration of ZNS within the dose examined. Moreover, the pharmacokinetic behaviors of ZNS were not altered after multiple dosing. The decreased t_<1/2> value of ZNS by PB or CBZ pretreatment and the increased Vd/F value of ZNS by VPA pretreatment were observed, although it showed no marked effect of PHT on ZNS kinetics. The enhanced metabolism of ZNS was observed by PB or CBZ pretreatmtent from an in vitro metabolism study. The serum protein binding and erythrocyte distribution of ZNS showed no significant change in the presence of other antiepileptics in vitro. These results indicate that the decreased t_<1/2> value of ZNS is attributable to the enzyme inducing effect of PB or CBZ, and that neither protein binding nor erythrocyte distribution of ZNS could be the reason for the increased Vd/F value of ZNS by VPA coadministration.
- 公益社団法人日本薬学会の論文
著者
-
Kimura Masahiko
Department of Pediatrics, Shimane Medical University
-
Kimura Masahiko
Department Of Astrophysics Nagoya University
-
Kimura M
Health Science Center At San Antonio The University Of Texas
-
Tanaka Naomi
Department of Pathology, Tochigi Institute of Clinical Pathology
-
Tanaka Naomi
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
-
Tanaka Naomi
Department Of Pharmaceutical Services Hiroshima University Hospital
-
Kimura M
Tsumura & Co. Ltd. Ibaraki Jpn
-
Kimura Masayasu
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
-
Miyake Katsushi
Department Of Pharmaceutical Services Hiroshima University Hospital
-
KIMURA Yasuhiro
Department of Biophysics, Kanazawa University School of Medicine
-
Kimura M
Taisho Pharmaceutical Co. Ltd. Saitama Jpn
-
KITAURA Teruaki
Department of Pharmaceutical Services, Hiroshima University Hospital
-
FUKUCHI Hiroshi
Department of Pharmaceutical Services, Hiroshima University Hospital
-
Tanaka Naomi
Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine University Of Tsukuba
-
Fukuchi Hiroshi
Department Of Clinical Radiology Faculty Of Health Sciences Hiroshima International University
-
Kitaura Teruaki
Department Of Pharmacy Chugoku Central Hospital
-
Kimura Yasuhiro
Department Of Pharmaceutical Services Hiroshima University Hospital : Division Of Clinical Pharmacot
-
KADOYAMA MASAYUKI
Department of Pharmaceutical Services, Hiroshima University Hospital
-
Kadoyama Masayuki
Department Of Pharmaceutical Services Hiroshima University Hospital
-
Kimura Y
Towada Urologic Hospital Towada Jpn
-
Kimura Masahiko
Department Of Agricultural Engineering Faculty Of Agriculture Tottori University
-
Kimura Yasuhiro
Department Of Biophysics Kanazawa University School Of Medicine
-
KIMURA Yasuhiro
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
関連論文
- Fibre Multi-Object Spectrograph (FMOS) for the Subaru Telescope
- Pilot study on neonatal mass screening for inborn errors of metabolism by gas chromatography-mass spectrometry : eighteen months experience in Shimane Area
- DESENSITIZING NEUROMUSCULAR BLOCKADE BY p-PHENYLENE-POLYMETHYLENE BIS-AMMONIUM COMPOUNDS DEVELOPED FROM SUCCINYLCHOLINE
- Urinary organic acids in peroxisomal disorders : a simple screening method
- Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae
- Diesel Exhaust Exposure Enhances the Persistence of Endometriosis Model in Rats
- High-Resolution Images of the Ring Nebula Taken with the Subaru Telescope
- Inhibitory Effects of Tetrandrine and Related Synthetic Compounds on Angiogenesis in Streptozotocin-Diabetic Rodents
- Inhibitory Effects of Tetrandrine on Angioegnesis in Adjuvant-Induced Chronic Inflammation and Tube Foramation of Vascular Endothelial Cells
- Inhibitory Effect of Magnosalin Derived from Flos magnoliae on Tube Formation of Rat Vascular Endothelial Cells during the Angiogenic Process
- The Diabetic State Increases the Activity but Not the Number of Peritoneal Macrophages in the GK Rat Promoting the Tube Formation of Cultured Endothelial Cells in Rat Aorta
- Suppression by High Glucose Concentration of Insulin Receptor Up-Regulation in Diaphragm and Flexor Digitorum Brevis Muscles from Diabetic KK-CA^y and Streptozotocin-Diabetic Mice
- Diabetic State-Induced Modification of Insulin-Stimulated, Glucose Uptake into and Kinase Activity in, the Diaphragm Muscle of Genetically Diabetic KK-CA^y Mice
- Perspective of Phospholipase A_2 involved in Acetylcholine Receptor Cluster Formation of Mouse Myotubes co-cultured with Spinal Cord Explant
- COMPARISON OF MECHANISMS OF ACTIONS BETWEEN CHOLECYSTOKININ AND PAPAVERINE FOR RELAXING A SPHINCTER OF ODDI IN HOG
- IMMUNOCHEMICAL EVIDENCE FOR INTERACTION BETWEEN CHOLECYSTOKININ C-TERMINAL PEPTIDES AND THE PROTEIN INHIBITOR OF ADENOSINE 3', 5'-CYCLIC MONOPHOSPHATE DEPENDENT PROTEIN KINASE IN HOG TERMINAL BILE DUCTS
- A Chain of Dark Clouds in Projection Against the Galactic Center
- Mutations identified in the human multidrug resistance P-glycoprotein 3 (ABCB4) gene in patients with primary hepatolithiasis
- Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome
- Subaru First-Loght Deep Photometry of Galaxies in A 851 Field
- Search for Outer Massive Bodies around Transiting Planetary Systems : Candidates of Faint Stellar Companions around HAT-P-7
- Competence Effect of Basic Fibroblast Growth Factor on Cell Cycle in Subcultured Endothelial Cells of Rat Aorta by Flow Cytometry
- Inhibitory Effects of Traditional Chinese Medicine Shimotsu-to and Its Included Crude Fractions on Adjuvant-Induced Chronic Inflammation of Mice
- The 2006 November Outburst of EG Aquarii : the SU UMa Nature Revealed
- Discovery of a WZ Sge-Type Dwarf Nova, SDSS J102146.44+234926.3 : Unprecedented Infrared Activity during a Rebrightening Phase
- The IRSF Magellanic Clouds Point Source Catalog
- Near-Infrared Polarization Images of the Orion Molecular Cloud 1 South Region
- Near-Infrared Imaging Polarimetry of the NGC 2071 Star-Forming Region with SIRPOL
- Evolution of Elliptical Galaxies at z * 1 Revealed from a Large, Multicolor Sample of Extremely Red Objects
- Multi-Object Infrared Camera and Spectrograph (MOIRCS) for the Subaru Telescope : I. Imaging
- Subaru/MOIRCS Near-Infrared Imaging in the Proto-Cluster Region at z = 3.1
- MOIRCS Deep Survey. II : Clustering Properties of K-Band Selected Galaxies in GOODS-North Region
- MOIRCS Deep Survey. I : DRG Number Counts
- Combined Potentiating Effects of Byako-ka-ninjin-to, Its Constituents, Rhizomes of Anemarrhena asphodeloides, Timosaponin A-III, and Calcium on Pilocarpine-Induced Salvia Secretion in Streptozocin-Diabetic Mice
- The Streptozocin-Diabetic State Depresses Saliva Secretion Stimulated by Pilocarpine and Noradrenaline in Mice
- INVOLVEMENT OF GLUCOCORTICOID IN INSULIN-INDUCED ANGIOGENESIS OF ADJUVANT POUCH GRANULOMA IN DIABETIC MICE
- QUANTITATIVE METHOD FOR MEASURING ADJUVANT-INDUCED GRANULOMA ANGIOGENESIS IN INSULIN-TREATED DIABETIC MICE
- MOUSE GRANULOMA POUCH INDUCED BY FREUND'S COMPLETE ADJUVANT WITH CROTON OIL
- An Improved Endoscopic Variceal Ligator for Esophagogastric Varix : Three-O-Band-Shooter
- Molecular analysis of AVPR2 gene in a Japanese patient With X-linked nephrogenic diabetes insipidus, congenital heart disease and mental retardation
- Gas chromatographic-mass spectrometric screening for organic acidemias using dried urine filter paper : determination of α-ketoacids
- Gas chromatography-mass spectrometry with tert.-butyldimethylsilyl derivatization : use of the simplified sample preparations and the automated data system to screen for organic acidemias
- Gas chromatography-mass spectrometry with tert. -butyldimethylsilyl derivatization : use of the simplified sample preparations and the automated data system to screen for organic acidemias
- Prenatal diagnosis for organic acid disorders using two mass spectrometric methods, gas chromatography mass spectrometry and tandem mass spectrometry
- A survey of Japanese patients with mitochondrial fatty acid β-oxidation and related disorders as detected from 1985 to 2000
- Rapid, simplified and sensitive method for screening fructose-1, 6-diphosphatase deficiency by analyzing urinary metabolites in urease/direct preparations and gas chromatography-mass spectrometry in the selected-ion monitoring mode
- Steroid-refractory severe ulcerative colitis responding to cyclosporine and long-term follow-up
- Fine Structural and Morphometric Studies on Gastric Parietal Cells of Peptic Ulcer Patients after Long-Term Treatment with Omeprazole
- Clinical and biochemical studies on Chinese patients with methylmalonic acidumia
- Clinical onset and prognosis of Asian children with organic acidemias, as detected by analysis of urinary organic acids using GC/MS, instead of mass screening
- Practical Assay Method of Cytosolic Acetoacetyl-CoA Thiolase by Rapid Release of Cytosolic Enzymes from Cultured Lymphocytes Using Digitonin
- Distal myopathy with rimmed vacuoles in a case of opercular syndrome
- Two Japanese families with hyperekplexia who have a Arg271Gln mutation in the glycine receptor alpha 1 subunit gene
- Enzymatic diagnosis of medium-chain acyl-CoA dehydrogenase deficiency by detecting 2-octenoyl-CoA production using high-performance liquid chromatography : A practical confirmatory test for tandem mass spectrometry newborn screening in Japan
- Serial magnetic resonance angiography in cerebral infarction after varicella infection
- A Variant case of congenital bilateral perisylvian syndrome with asymmetric findings on neuroimaging and septum pellucidum defect
- A case of West syndrome well controlled by very short and low-does ACTH therapy
- Prenatal and postnatal evaluation of Dandy-Walker malformation : a case report
- Brain holding spells in early infancy
- Clinical study of partial epilepsies occurring before two years of life
- Multiple regression analysis for assesing the growth of small hepatocellular carcinoma: The MIB-1 labeling index is the most effective parameter
- Severe acute hepatitis A associated with acute pure red cell aplasia
- Multivariate analysis of risk factors for hepatocellular carcinoma in patients with hepatitis C virus-related liver cirrhosis
- MOIRCS Deep Survey. I: DRG Number Counts
- Pancreaticoduodenal artery aneurysms associated with celiac axis stenosis due to compression by median arcuate ligament and celiac plexus
- Isolated 3-methylcrotonyl-CoA carboxylase deficiency in a 15-year-old girl
- Aconitine, a Main Component of Aconite, Increases Spontaneous Acetylcholine Release from the Frontal Cerebral Cortex of Freely Moving Rats
- ACETYLCHOLINE RECEPTOR-OPERATED INTRACELLULAR CALCIUM MOBILIZATION MODIFIED BY DIABETIC STATE IN SKELETAL MUSCLE
- DEVELOPMENTALLY DELAYED SENSITIVITY OF ACETYLCHOLINE RECEPTOR IN MYOTUBES OF NERVE-MUSCLE COCULTURES FROM GENETICALLY DIABETIC MOUSE EMBRYOS
- HYPERSENSITIVITY OF ACETYLCHOLINE RECEPTOR IN DIABETIC SKELETAL MUSCLE TO NEUROMUSCULAR BLOCKERS : THE EFFECT ON MYOTUBES CULTURED WITH SPINAL CORD OR ITS EXTRACT
- The harmful effect of exercise on reducing taurine concentration in the tissues of rats treated with CCl_4 administration
- Amino acid ratios in plasma and tissues in a rat model of liver cirrhosis before and after exercise
- Degeneration of skeletal muscle fibers in the rat administrated carbon tetrachloride : similar histological findings of the muscle in a 64-year-old patient of LC with muscle cramp
- Chemical Structural Requirement in Gingerol Derivatives for Potentiation of Prostaglandin F_-Induced Contraction in Isolated Mesenteric Veins of Mice
- Deep-Imaging Observations of a Candidate of an Absorbed QSO at z=0.653, AX J131831+3341
- A severely brain-damaged case of 3-hydroxyisobutyric aciduria
- MOIRCS deep survey (10) Evolution of quiescent galaxies as a function of stellar mass at 0.5 < z < 2.5 (Special issue: Exploring the universe with the Subaru Telescope: from galaxies to the solar system)
- MOIRCS deep survey (9) Deep near-infrared imaging data and source catalog (Special issue: Exploring the universe with the Subaru Telescope: from galaxies to the solar system)
- MOIRCS deep survey (7) NIR morphologies of star-forming galaxies at redshift z〜1 (Special issue: Exploring the universe with the Subaru Telescope: from galaxies to the solar system)
- Pharmacokinetic Interaction of Zonisamide in Rats. Effect of Other Antiepileptics on Zonisamide
- Pharmacokinetic Analysis of Amitriptyline and Its Demethylated Metabolite in Serum and Brain of Rats after Acute and Chronic Oral Administration of Amitriptyline
- Ocular Pharmacokinetics of Latamoxef and Cefaclor in Humans. Penetration into Aqueous Humor
- Ocular Pharmacokinetics of Latamoxef and Cefaclor in Rabbits. Penetration into Aqueous Humor
- PROLONGATION OF LIFE SPAN OF DYSTROPHIC HAMSTER BY CYSTEINE PROTEINASE INHIBITOR, LOXISTATIN (EST)
- Screening for fatty acid beta oxidation disorders Acylglycine analysis by electron impact ionization gas chromatography-mass spectrometry
- The Acetylcholine-Hypersensitive Model of Diabetic KK-CA^y Mice Analyzed with Pulse Rate, and Modified by Repeated Cold Stress and by Adrenalectomy
- Automated Metabolic Profiling and Interpretation of GC/MS Data for Organic Acidemia Screening : A Personal Computer-Based System
- ASSESSMENT OF LEFT INTERNAL MAMMARY ARTERY BYPASS GRAFT PATENCY BY DOPPLER ECHOGRAPHY : THE EXAMINATION FROM LEFT SUPRACLAVICULAR FOSSA : Echocardiography, Pulsed Doppler : 53 Annual Scientific Meeting, Japanese Circulation Society
- Relapse patterns of localized non-Hodgkin's lymphoma of the head and neck after clinical remission: results of a strict follow-up procedure
- Relapsed Non-Hodgkin's Lymphoma: Detection and Treatment
- Radiotherapy for Localized Relapse in Patients with Non-Hodgkin's Lymphoma:A Preliminary Report
- Bosentan, a novel synthetic mixed-type endothelin receptor antagonist, attenuates acute gastric mucosal lesions induced by indomethacin and HCl in the rat: Role of endogenous endothelin-1
- Efficacy of Intravascular Ultrasound-guided Stent Implantation
- Seizure recurrence after reduction of an antiepileptic drug in patients with unprovoked seizures and severe neurological abnormalities
- Effect of antiepileptic drugs on thyroid function
- Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide : A case report
- Carbamazepine-exacerbated epilepsy with multifocal shifting independent epileptiform discharges on electroencephalogram : A case report
- Structural Strength Analysis of Tractor Members Using Finite Element Method : I. Programs for truss and Rahmen Structures
- Advantage of Cine-MR Imaging for the Evaluation of Valvular Regurgitation : 53th Annual Scientific Session of the Japanese Circulation Society
- A Genetically Diabetic Model “KK-CAy Mice” for a Pharmacological Assay