Bosentan, a novel synthetic mixed-type endothelin receptor antagonist, attenuates acute gastric mucosal lesions induced by indomethacin and HCl in the rat: Role of endogenous endothelin-1
スポンサーリンク
概要
著者
-
NAKAHARA Akira
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
-
FUKUTOMI Hisayuki
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
-
Goto Katsutoshi
Departments of Internal Medicine, Surgery, Pharmacology, University of Tsukuba
-
Tanaka Naomi
Department of Pathology, Tochigi Institute of Clinical Pathology
-
Hirano K
Univ. Tokyo Tokyo Jpn
-
Tanaka Naomi
Division Of Gastroenterology Department Of Internal Medicine Institute Of Clinical Medicine Universi
-
Tanaka Naomi
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
-
Nakahara A
筑波大学 大学院人間総合科学研究科消化器病学
-
Nakahara Akira
Department Of Gastroenterology Institute Of Clinical Medical Sciences University Of Tsukuba
-
KASHIMURA HIROMASA
Department of Internal Medicine, Division of Gastroenterology, University of Tsukuba
-
HASSAN MAHMUDUL
Department of Internal Medicine, Division of Gastroenterology, University of Tsukuba
-
MATSUMARU KAZUHIKO
Department of Internal Medicine, Division of Gastroenterology, University of Tsukuba
-
MUTO HIROSHI
Department of Internal Medicine, Division of Gastroenterology, University of Tsukuba
-
Muto H
Shinshu Univ. School Of Medicine Matsumoto Jpn
-
Fukutomi H
Departments Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
-
Fukutomi Hisayuki
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
-
Kashimura Hiromasa
Division Of Gastroenterology Department Of Internal Medicine Institute Of Clinical Medicine Universi
-
Goto Katsutoshi
Department Of Pharmacology Institute Of Basic Medical Sciences The University Of Tsukuba
-
Matsui Hirofumi
Division Of Gastroenterology Institute Of Clinical Medicine University Of Tsukuba
-
Matsui Hirofumi
Tohoku University Graduate School Of Medicine
-
Matsui Hirofumi
Division Of Gastroenterology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
-
Tanaka Naomi
Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine University Of Tsukuba
-
Matsui H
Ehime Univ. Graduate School Of Medicine Ehime Jpn
-
IWATA Riko
Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd.,
-
HAYASHI Takashi
Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd.,
-
Matsui Hirofumi
Graduate School Of Comprehensive Human Sciences And Center For Tsukuba Advanced Research Alliance Ex
-
MOTOHASHI Hozumi
Tohoku University Graduate School of Medicine
-
Iwata R
Pharmaceutical Research Laboratory Hitachi Chemical Co. Ltd.
-
Iwata Riko
Pharmaceutical Research Laboratory Hitachi Chemical Co. Ltd.
-
Hassan Mahmudul
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
-
Matsumaru Kazuhiko
Department Of Internal Medicine Division Of Gastroenterology University Of Tsukuba
-
Nakahara Akira
Department Of Biological Sciences Yamaguchi University
-
Kashimura Hiromasa
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
-
Nakahara Akira
Univ. Tsukuba Tsukuba Jpn
-
Hayashi Takashi
Pharmaceutical Research Laboratory Hitachi Chemical Co. Ltd.
-
Goto Katsutoshi
Department Of Ophthalmology Kawasaki Medical School
関連論文
- The Fate of Effete Epithelial Cells at the Villus Tips of the Human Small Intestine
- -0902- ENDOTHELIN RECEPTOR SUBTYPES IN THE PULMONARY ARTERIAL SMOOTH MUSCLES AND BRONCHIAL SMOOTH MUSCLES IN HUMANS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- 0882 ENDOTEHLIN RECEPTOR SUBTYPES IN HUMAN UTERINE SMOOTH MUSCLES
- PJ-393 Changes of Myocardial Endothelin-1 Level during the Formation of Exercise Training-induced Cardiac Adaptation(Exercise test/Cardiac rehabilitation-3 (IHD) PJ66,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- PE-243 Endothelin Receptor Antagonist Ameliorates the Cardiac Dysfunction, Decreased Cardiac VEGF Signaling and Inadequate Coronary Collateral Development in Early Diabetic Rats(Diabetes/Obesity/Metabolic syndrome-8 (H) PE41,Poster Session (English),The 7
- PE-188 Dual Endothelin Receptor Antagonist Reverses the Upregulated VEGF-KDR Axis in Frontal Cortex of SHR-SP without Modulating the Cerebral Blood Flow(Cerebrovascular circulation/Stroke-2 (IHD) PE32,Poster Session (English),The 70th Anniversary Annual S
- OE-298 Eicosapentaenoic Acid, a Major Component of Fish Oil, Prevents the Progression of Endothelin-1-Induced Cardiomyocyte Hypertrophy through Suppressing Phosphorylated JNK(Cardiovascular pharmacology, basic/clinical-1 (H) OE50,Oral Presentation (Englis
- Diesel Exhaust Exposure Enhances the Persistence of Endometriosis Model in Rats
- Mutations identified in the human multidrug resistance P-glycoprotein 3 (ABCB4) gene in patients with primary hepatolithiasis
- Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome
- -0827-PLASMA CONCENTRATIONS OF ENDOTHELIN-1 AMD BIG ENDOTHELIN-1 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Bio-Assessment of RISK in Long-Term Manned Space Exploration : Cell Death Factors in Space Radiation and/or Microgravity : A Review
- An Improved Endoscopic Variceal Ligator for Esophagogastric Varix : Three-O-Band-Shooter
- Poor Survival of Cardiomyopathic Hamsters with CHF Is Greatly Improved by Combined Treatment with Endothelin (ET)-A Receptor Antagonist and ACE Inhibitor
- IS097 Chronic treatment with endothelin inhibitor greatly improves survival in hamsters with heart failure due to dilated cardiomyopathy : increased expression of endothelin-1 in failing heart
- Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines
- Autofluorescence in indomethacin-induced gastric mucosal lesions in rats
- Steroid-refractory severe ulcerative colitis responding to cyclosporine and long-term follow-up
- Fine Structural and Morphometric Studies on Gastric Parietal Cells of Peptic Ulcer Patients after Long-Term Treatment with Omeprazole
- Monitoring of hepatocellular carcinoma, following proton radiotherapy, with contrast-enhanced color Doppler ultrasonography
- Multiple regression analysis for assesing the growth of small hepatocellular carcinoma: The MIB-1 labeling index is the most effective parameter
- Severe acute hepatitis A associated with acute pure red cell aplasia
- Multivariate analysis of risk factors for hepatocellular carcinoma in patients with hepatitis C virus-related liver cirrhosis
- New, Effective Treatment Using Proton Irradiation for Unresectable Hepatocellular Carcinoma
- Pancreaticoduodenal artery aneurysms associated with celiac axis stenosis due to compression by median arcuate ligament and celiac plexus
- Transforming growth factor-alpha (TGF α)-producing gastric carcinoma with acanthosis nigricans: An endocrine effect of TGF αin the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus.
- Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone
- The harmful effect of exercise on reducing taurine concentration in the tissues of rats treated with CCl_4 administration
- Amino acid ratios in plasma and tissues in a rat model of liver cirrhosis before and after exercise
- Degeneration of skeletal muscle fibers in the rat administrated carbon tetrachloride : similar histological findings of the muscle in a 64-year-old patient of LC with muscle cramp
- OE-176 Endothelin-1 Induces the Expressions of VEGF and Its Receptors (Flt-1 and Flk-1) in Neonatal Cardiomyocytes in Vitro Dosedependently(Neurohumoral factors-1 (H) OE30,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the J
- PJ-042 Effects of Athletic Strength- and Endurance-exercise Training on Aortic Stiffness and Plasma Endothelin-1 Concentration in Young Humans(Exercise test/Cardiac rehabilitation-5 (IHD) PJ7,Poster Session (Japanese),The 70th Anniversary Annual Scientifi
- P784 DOES MYOCARDIAL ENDOTHELIN-1 PARTICIPATE IN THE MODULATION OF CARDIAC FUNCTION DURING EXERCISE?
- P627 EXPRESSION OF ENDOTHELIN RECEPTOR SUBTYPBS AND ANGIOTENSIN RECEPTOR SUBTYPES IN THE HEART OF RATS WITH CHRONIC HEART FAILURE
- -1090-IMPORTANCE OF CALCITONIN GENE-RELATED PEPTIDE (CGRP)-CONTAINING NERVES IN THE REGULATION OF HUMAN VASCULAR TONUS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Cardiac hypertrophic respones by acute prenaure-overload in reduced in cardiomyocyte-upecitic endothelin-1-knockout mice
- Cardiovascular Effects of Endothelin : ROLES OF VASCULAR ENDOTHELIUM IN REGULATION OF CARDIOVASCULAR SYSTEM
- Hydrogen peroxide-induced cellular injury is associated with increase in endogenous fluorescence from rat gastric mucosal epithelial cell culture : A new method for detecting oxidative cellular injury by fluorescence measurement
- Elucidation With the Protease α-Chymotrypsin of the Inhibitory Modulating Action of Endogenous Neuropeptide Y Over Sympathetic Neurotransmission in Rat Vas Deferens
- Cellular membrane fluidity measurement by fluorescence polarization in indomethacin-induced gastric cellular injury in vitro
- PATHOPHYSIOLOGICAL ROLES OF ENDOTHELIN-1 IN PULMONARY HYPERTENSIVE RATS
- Decreases in Exercise Capacity, Myocardial Energy Metabolism, and Survival in Rats with CHF Are Greatly Improved by Endothelin-A Receptor Antagonist
- Endogenous endothelin (ET)-1 depresses both NOS activity and NO production in the kidney during exercise
- 0894 EXPRESSION OF ENDOTHELIN RECEPTOR MESSENGER RNA IN THE CONGESTIVE LUNG IN RATS WITH CHRONIC HEART FAILURE
- 0884 ENDOTHELIN CONVERTING ENZYME AND ANGIOTENSIN CONVERTING ENZYME IN THE HEART OF RATS WITH CHRONIC HEART FAILURE
- 0804 EXPRESSION OF ENDOTHELIN-1 mRNA IN THE HEART OF PATHOLOGICAL HYPERTROPHY OR PHYSIOLOGICAL HYPERTROPHY
- 0234 Treatment with an Endothelin Receptor Antagonist Ameliorates Chronic Heart Failure in Rats and Inhibits the Alteration of the Expression of Cardiac Genes
- Clinical characteristics of autoimmune hepatitis in older aged patients
- Hepatocyte-Specific Deletion of Heme Oxygenase-1 Disrupts Redox Homeostasis in Basal and Oxidative Environments
- Pharmacokinetic Interaction of Zonisamide in Rats. Effect of Other Antiepileptics on Zonisamide
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. I. A COMPARISON OF THE EFFECT ON PRE- AND POSTSYNAPTIC α-ADRENOCEPTORS IN THE RAT VAS DEFERENS
- Endothelin ET_A and ET_B Receptors Mediate Endothelin-1-Induced Apamin-Sensitive Relaxation in the Guinea Pig Ileum
- ENDOSCOPIC CLASSIFICATION OF CHRONIC GASTRITIS BASED ON A PILOT STUDY BY THE RESEARCH SOCIETY FOR GASTRITIS
- -0705- Endothelin-1 and cardiac hypertrophy due to pressure or volume overload in rats(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0657- Effects of an endothelin-A receptor antagonist on the pulmonary hypertension caused by congestive heart failure in Rats(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- The Production of Endothelin-1 in the Heart is Altered in Rats with Heart Failure
- The Production of Endothelin-1 in the Hypertrophied Rat Heart due to Pressure or Volume Overload
- Primary tubular adenocarcinoma arising in the duodenal limb of reconstructed gastroduodenostomy for signet-ring cell carcinoma of the stomach
- Venous tumor thrombosis and cavernous transformation of the portal vein in a patient with gastric carcinoma
- Sensitive Chemiluminescent Enzyme Immunoassay for Determination of Endothelin-1
- Orexin Receptor Type-1 Couples Exclusively to Pertussis Toxin-Insensitive G-Proteins, while Orexin Receptor Type-2 Couples to Both Pertussis Toxin-Sensitive and *Insensitive G-Proteins
- Telomerase activity and expression of human telomerase catalytic subunit gene in esophageal tissues
- Primary diaphragmatic schwannoma with a typical target appearance: Correlation of CT and MR imagings and histologic findings
- Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-γ production in mice but does not suppress T_h2-cytokine production or antibody production
- Prevention of black pigment gallstone formation after cardiac surgery by ursodeoxycholic acid
- Bosentan, a novel synthetic mixed-type endothelin receptor antagonist, attenuates acute gastric mucosal lesions induced by indomethacin and HCl in the rat: Role of endogenous endothelin-1
- L-arginine and endogenous nitric oxide protect the gastric mucosa from endothelin-1-induced gastric ulcers in rats
- Accumulation of 7α-hydroxycholesterol in liver tissue of patients with cholesterol gallstones
- Increased bile acid concentration in liver tissue with cholesterol gallstone disease
- Advantage of Body Surface Area on Dose Adjustment of Antiepileptic Drugs
- Clinical significance of the trimethadione tolerance test in chronic hepatitis: A useful indicator of hepatic drug metabolizing capacity
- Progression of autoimmune-mediated hepatic lesions in a murine graft-versus-host reaction by neutralizing IL-10
- Progression of autoimmune-mediated hepatic lesions in a murine graft-versus-host reaction by neutralizing IL-10
- Combination of endothelin-A (ET_A) receptor inhibitor and prostacyclin (PGI_2) analogue is preferable to each drug alone for pulmonary hypertension (PH)
- Corresponding distributions of increased endothelin-B receptor expression and increased endothelin-1 expression in the aorta of apolipoprotein E-deficient mice with advanced atherosclerosis
- Clinical significance of serum total bile acids and indocyanine green test for the estimation of plasma free etoposide ratio in anicteric hepatocellular carcinoma patients
- Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model
- Basic and Therapeutic Relevance of Endothelin-Mediated Regulation
- Molecular Pharmacology and Pathophysiological Significance of Endothelin
- DEPLETION OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) BY CAPSAICIN IN CEREBRAL ARTERIES
- A COMPARATIVE STUDY OF CHANGES IN INNERVATION AND DEVELOPMENT OF SUPERSENSITIVITY IN THE RAT VAS DEFERENS AFTER VARIOUS PROCEDURES
- 1123 Treatment with an Endothelin Receptor Antagonist Ameliorates Chronic Heart Failure in Rats
- -P402- Study of endothelin-1-like immunoreactivity in the lung of rats with pulmonary hypertension caused by monocrotaline(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- PULMONARY VASCULAR RESPONSES TO VARIOUS VASODILATOR AGENTS IN RATS WITH PULMONARY HYPERTENTSION
- CARDOVASCULAR EFFECTS OF AMYLIN,A NOVEL PANCREATIC HORMONE
- Mechanism of Heme Uptake by Heme Acquisition System A
- Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model
- CLINICAL INVESTIGATION : Factors affecting imaging of spectral-domain optical coherence tomography in gas-filled eyes after macular-hole surgery
- Factors affecting imaging of spectral-domain optical coherence tomography in gas-filled eyes after macular-hole surgery
- Analysis of New Imidazoline Derivative-Induced Increase in the Maximum Response to Norepinephrine in the Rat Vas Deferens
- Pressor response to endothelin in guinea pigs.
- Endothelin-1-Induced Phosphorylation of the 20-kDa Myosin Light Chain and Caldesmon in Porcine Coronary Artery Smooth Muscle.