Pressor response to endothelin in guinea pigs.
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概要
- 論文の詳細を見る
Endothelin (ET), an endothelium-derived vasoconstrictor peptide, was injected into the jugular vein (i.v.) of guinea pigs anesthetized with urethane. Blood pressure was measured from a cannula inserted into the carotid artery. All experiments were carried out after treatment with adrenergic and cholinergic antagonists. ET showed a potent, dose-dependent pressor action in guinea pigs. However, the initial, transient depressor response which is observed in rats was not produced in guinea pigs. Nicardipine (0.1 mg/kg), a dihydropyridine Ca<SUP>2+</SUP>-channel blocker, significantly inhibited the ET-induced pressor response. These results suggest that ET causes a potent pressor response, which appears to be related to the activation of Ca<SUP>2+</SUP> channels.
- 公益社団法人 日本薬理学会の論文
著者
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Yanagisawa Masashi
Department Of Molecular Genetics The University At Texas Southwestern Medical Center
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LI Liming
Department of Photonics Material Science, Chitose Institute of Science and Technology
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Miyauchi Takashi
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
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Kimura Sadao
Department Of Internal Veterinary Medicine Faculty Of Veterinary Medicine Hokkaido University
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Masaki Tomoh
Department Of Bioscience National Cardiovascuar Center Reserch Institute
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Ishikawa Tomohisa
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Goto Katsutoshi
Department Of Ophthalmology Kawasaki Medical School
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ISHIKAWA Tomohisa
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba
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MIYAUCHI Takashi
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba
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YANAGISAWA Masashi
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba
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KIMURA Sadao
Department of Biochemistry, Institute of Basic Medical Science, University of Tsukuba
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LI Liming
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba
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MASAKI Tomoh
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba
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