Endothelin-1-Induced Phosphorylation of the 20-kDa Myosin Light Chain and Caldesmon in Porcine Coronary Artery Smooth Muscle.
スポンサーリンク
概要
- 論文の詳細を見る
Endothelin-1 (ET), a potent vasoconstrictor, induces a sustained increase in the phosphorylation level of the 20-kDa myosin light chain (MLC) in porcine coronary artery strips. ET also induces late phosphorylation of caldesmon, which is mimicked by 12-deoxyphorbol 13-isobutyrate, but not by 60 mM KCl. Nitroglycerin, a vasorelaxant, completely reverses the ET-induced phosphorylation of MLC, but not that of caldesmon. These results suggest an important regulatory role of MLC phosphorylation in ET-induced contraction.
- 公益社団法人 日本薬理学会の論文
著者
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Takuwa Yoh
Department Cardiovascular Biology University Of Tokyo
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Abe Yoichiro
Department Of Pharmacology Institute Of Basic Medical Sciences University Of Tsukuba
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Yamashita Kamejiro
Department Of Internal Medicine Institute Of Clinical Medicine University Of Tsukuba
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Kasuya Yoshitoshi
Department Of Pharmacology Institute Of Basic Medical Sciences The University Of Tsukuba
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Masaki Tomoh
Department Of Bioscience National Cardiovascuar Center Reserch Institute
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Goto Katsutoshi
Department Of Ophthalmology Kawasaki Medical School
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Kasuya Yoshitoshi
Departments of Pharmacology, University of Tsukuba School of Medicine
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Kudo Michiyo
Departments of Internal Medicine, University of Tsukuba School of Medicine
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Yamashita Kamejiro
Departments of Internal Medicine, University of Tsukuba School of Medicine
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Takuwa Yoh
Departments of Internal Medicine, University of Tsukuba School of Medicine
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