Facilitation of L-type Ca^<2+> Currents by Fluid Flow in Rabbit Cerebral Artery Myocytes
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概要
- 論文の詳細を見る
Blood vessels are receptive to hemodynamic forces, such as blood pressure and flow, which result in myogenic responses. The present study aimed to investigate the effect of mechanical stresses on L-type voltage-dependent Ca2+ channels in rabbit cerebral artery myocytes. Cell swelling induced by the exposure to a 16% hypotonic solution increased peak values of whole-cell Ba2+ currents (IBa). Similarly, an elevation of bath perfusion rate increased peak values of IBa. However, the response was reduced by the continued fluid flow stimulation and the current amplitude almost returned to the baseline. This reduction of the current was abolished by pretreatment with thapsigargin, implying the contribution of Ca2+ release from the sarcoplasmic reticulum to the response. These results suggest that L-type Ca2+ currents are facilitated not only by cell swelling but also by fluid flow in cerebral artery myocytes.
- 社団法人 日本薬理学会の論文
- 2005-08-20
著者
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AMANO Satoshi
Department of Biotechnology, Graduate School of Engineering, Osaka University
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ISHIKAWA Tomohisa
Department of Neuropsychiatry, Ehime University Medical School
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NAKAYAMA Koichi
Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Iwate Medical
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Amano Satoshi
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Amano Satoshi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Nakayama Koichi
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Iwate Medical U
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Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Ishikawa Tomohisa
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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