Structure and Molecular Assembly of the Dermal-Epidermal Attachment Complex in Skin

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概要

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• The basement membrane between the epidermis and the dermis contains unique structures that maintains the attachment of the epithelium. The components of the attachment complex provide links to the intracellular intermediate filament network of basal keratinocytes and to the extracellular matrix of the papillary dermis. One of the key components of the anchoring complex is laminin 5. Laminin 5 is essential to epidermal attachment, as genetic mutations in the laminin 5 genes couse the severe blistering phenotype of Herlitz's junctional epidermolysis bullosa. It is clear that laminin 5 binds the hemidesmosomal integrin α6β4, but the mechanism by which laminin 5 binds either components of the basement membrane or of the papillary dermis still remains incompletely understood. Recent research progress indicates the following results:(1)laminin 5 is uniformly distributed along the epidermal basement membrane while type VII collagen is concentrated under hemidesmosomes;(2)laminin 5 is extracted from tissues in two forms, as a monomer and as a covalent complex with laminin 6 or 7, and the laminin 5-6 / 7 complex can interact with other basement membrane components through an interaction mediated by nidogen;(3)laminin 5 binds the NH_2-terminal NC-1 domain of type VII collagen;(4)monomeric laminin 5 constitutes the anchoring filaments and bridges integrin α6β4 with type VII collagen;(5)in α3 integrin null mice, a normal basement membrane appears beneath the hemidesmosomes, but it lacks the basement membrane in the interhemidesmosomal regions. From these observations, we propose that monomeric laminin 5 is the major species contributing to the epidermal-dermal stability of attachment, while the laminin 5-6 / 7 complex contributes to the assembly and / or stability of the basement membrane between hemidesmosomes.

• 日本結合組織学会の論文
• 1998-09-25

著者

• NISHIYAMA Toshio

  Shiseido Life Science Research Center

• Burgeson Robert

  Cutaneous Biology Research Center Massachsetts General Hospital And Harvard Medical School

• Amano Satoshi

  Department Of Biotechnology Graduate School Of Engineering Osaka University

• Nishiyama Toshio

  Skin Biology Research Labs. Shiseido Life Science Research Center

• AMANO Satoshi

  Skin Biology Research Laboratories, Shiseido Research Center

• BURGESON Robert

  The Cutaneous Biology Research Center, Massachusettes General Hospital and Harvard Medical School

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