Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model
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概要
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Previous studies have shown that prenatal and postnatal exposure to diesel exhaust (DE), which is known to be one of the main constituents of air pollution, enhances the persistence of endometriosis in a rat model. The aim of this study is to investigate the pathological changes induced by DE exposure in a rat model of endometriosis. Pregnant Sprague-Dawley rats were exposed to DE or clean air beginning on gestational day 2 and neonatal rats were persistently exposed to DE or clean air. Endometriosis was induced by autotransplantation of endometrium onto the peritoneum of eight-week-old female offspring. Endometriotic lesions were examined at 7 and 14 days post-transplantation. As a result, infiltration of activated mast cells remained in deeper area of peritoneal tissue around the endometriosis model compared to the control group at 14 days post-autotransplantation. In the DE exposure group, 14 days post-transplant, the remaining lesions contained fibroblasts and activated mast cells, which were surrounded by collagen fibers. The data showed that prenatal and postnatal DE exposure enhances the activation of mast cells and prolongs the persistence of collagen fibers in the induced rat model of endometriosis.
- 日本トキシコロジー学会の論文
著者
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Umezawa Masakazu
東京理科大学 薬学部衛生化学
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Umezawa Masakazu
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Tabata Masako
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science
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Tanaka Naomi
Department Of Pathology Tochigi Institute Of Clinical Pathology:department Of Hygienic Chemistry Fac
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Sugamata Masao
Department Of Pathology Institute Of Tochigi Clinical Pathology Japan
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Tanaka Naomi
Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine University Of Tsukuba
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Ihara Tomomi
Department Of Pathology Institute Of Tochigi Clinical Pathology Japan
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Sakata Chika
Department Of Pathology Tochigi Institute Of Clinical Pathology:department Of Hygienic Chemistry Fac
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Takeda Ken
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science
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