Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice
スポンサーリンク
概要
- 論文の詳細を見る
Titanium dioxide (TiO2) nanoparticles are widely used in cosmetics, sunscreen and as a photocatalyst. However, little is known about the biological effect of TiO2 nanoparticles in humans and other animals. Here, we investigated whether prenatal exposure to TiO2 nanoparticles impacted the central nervous system in mice. We measured the levels of dopamine (DA) and its metabolites in several regions of the brain in mice using high performance liquid chromatography (HPLC). HPLC analysis showed that DA and its metabolites were increased in the prefrontal cortex and the neostriatum following prenatal exposure to TiO2 nanoparticles. The present study highlights the possibility that maternal exposure to TiO2 nanoparticles might influence the development of the central dopaminergic system in offspring.
- 2010-10-01
著者
-
TAKAHASHI Yuta
Department of Internal Medicine 2, Fukushima Medical University School of Medicine
-
Takeda Ken
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
-
Oshio Shigeru
Research Center For Health Science Of Nanoparticles Research Institute For Science And Technology To
-
MIZUO Keisuke
Research Center for Health Science of Nanoparticles, Research Institute for Science and Technology,
-
SHINKAI Yusuke
Research Center for Health Science of Nanoparticles, Research Institute for Science and Technology,
-
Takeda K
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
-
Mizuo Keisuke
Research Center For Health Science Of Nanoparticles Research Institute For Science And Technology To
-
Shinkai Yusuke
Research Center For Health Science Of Nanoparticles Research Institute For Science And Technology To
-
Takahashi Yuta
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science
-
Takeda Ken
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science
-
Takahashi Yuta
Department Of Gastroenterology And Rheumatology Fukushima Medical University School Of Medicine
-
Takeda Ken
The Center For Environmental Health Science For The Next Generation Research Institute Far Science And Technology Tokyo University Of Science
関連論文
- Novel insights into pathology of endometriosis from a disease model induced by autotransplantation of endometrium
- Early Development Origins of Adult Disease Caused by Malnutrition and Environmental Chemical Substances
- Pancreatobiliary drainage using the EUS-FNA technique : EUS-BD and EUS-PD
- Endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses with rapid on-site cytological evaluation by endosonographers without attendance of cytopathologists
- Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems
- Diesel Exhaust Exposure Enhances the Persistence of Endometriosis Model in Rats
- Maternal Exposure to Diesel Exhaust Leads to Pathological Similarity to Autism in Newborns
- Maternal Diesel Exhaust Exposure Damages Newborn Murine Brains
- Effect of Diesel Exhaust on Development of Fetal Reproductive Function in ICR Female Mice
- Maternal Exposure to Diesel Exhaust Decreases Expression of Steroidogenic Factor-1 and Mullerian Inhibiting Substance in the Murine Fetus
- Okadaic Acid Remarkably Suppresses Testosterone Production in Murine Leydig Cells
- Effect of Dibromochloropropane (DBCP) on the Hormone Receptors of the Male Rat Reproductive System
- Cortical Laminar Necrosis in a Patient with Moyamoya Disease Associated with Down Syndrome: MR Imaging Findings
- Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice
- Results of Radiation Therapy for Uterine Cervical Cancer Using High Dose Rate Remote After Loading System
- Myxoinflammatory fibroblastic sarcoma
- Soybean isoflavones preserve bone mass in hindlimb-unloaded mice
- Construction of X-ray Dark-Field Imaging with a View Size of 80mm Square and First Visualization of Human Articular Cartilage of Femoral Head under a Nearly Clinical Condition
- Diesel exhaust (DE) aggravates pathology of delayed-type hypersensitivity (DTH) Induced by methyl-bovine serum albumin (mBSA) in mice
- Predictive Factors for Acute Esophageal Toxicity in Thoracic Radiotherapy
- Comparison of Conjugative Activity, Conversion of Bisphenol A to Bisphenol A Glucuronide, in Fetal and Mature Male Rat
- Passage of Bisphenol A into the Fetus of the Pregnant Rat
- AN ELECTRONIC RADIAL SCANNING ECHOENDOSCOPE IS SUPERIOR TO A MECHANICAL RADIAL SCANNING ECHOENDOSCOPE IN ULTRASOUND IMAGE QUALITY FOR GASTROINTESTINAL TRACT AND PANCREATICOBILIARY LESIONS
- Complementary Assembly of Heterogenous Peptides into Amyloid Fibrils and Their Catalytic Function
- Peptides Undergoing Secondary Structural Transition and Self-Assembly into Amyloid Fibril Based on Structural Complementarity
- An α-to-β Structural Transition and Amyloidogenesis of Peptides : Effects of Amino Acid Substitution on Self-replicating Organization
- Design and Synthesis of Peptide Misfolding from α to β Structure and Regulation by β-Cyclodextrin as Mini-Molecular Chaperone
- Analysis of Responsive Genes of Murine Leydig Cells by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
- Microbial Degradation of Disinfectants : Two New Aromatic Degradation Products of Chlorhexidine, Chlorhexidine Aromatic Degradation Product (CHADP)-4 and CHADP-6, Produced by Pseudomonas sp. Strain No. A-3
- Acrinol Degradation Products (ANDP)-8, A Novel Acrinol Degradation Product by Light
- Tumor-Promoting Activity of Phthalate Esters Estimated by in Vitro Transformation Using Bhas Cells
- Characterization of Human Salivary Esterase in Enzymatic Hydrolysis of Phthalate Esters
- Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing
- ^F-fluorodeoxyglucose positron emission tomography immediately after chemoradiotherapy predicts prognosis in patients with locoregional postoperative recurrent esophageal cancer
- Proteome Analysis of the Effects of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin on Murine Testicular Leydig and Sertoli Cells
- Postoperative deep infection in tumor endoprosthesis reconstruction around the knee
- Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Testosterone Production in Isolated Murine Testicular Cells
- 5-Aza-2-deoxycytidine reactivates the CDH1 gene without influencing methylation of the entire CpG island or histone modification in a human cancer cell line
- Predicting the Severity of Acute Urinary Toxicity after Brachytherapy with Iodine-125 for Localized Prostate Cancer
- Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model
- Identification of the Anti-Adhesive Site Buried within the Heparin-Binding Domain of Fibronectin
- Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring
- Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression
- ANALYSIS OF PROGNOSTIC FACTORS IN PATIENTS WITH GASTRIC VARICES AFTER ENDOSCOPIC TREATMENT
- Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model
- Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring
- Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression
- ATP assay-guided chemosensitivity testing for gemcitabine with biopsy specimens obtained from unresectable pancreatic cancer using endoscopic ultrasonography-guided fine-needle aspiration
- 2-B-05 Comparison of spontaneous and forced running on the hypothalamic gene expression using microarray and Medical Subject Headings analysis(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (To
- Evaluation of the testicular toxicity of prenatal exposure to bisphenol A based on microarray analysis combined with MeSH annotation
- Effect of fetal exposure to titanium dioxide nanoparticle on brain development-brain region information
- Gastric Antral Vascular Ectasia (GAVE) Associated with Systemic Sclerosis: Relapse after Endoscopic Treatment by Argon Plasma Coagulation
- A CASE OF TRANSGASTRIC GALLBLADDER PUNCTURE AS A COMPLICATION DURING ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF A PANCREATIC PSEUDOCYST
- TWO CASES OF PANCREATIC ABSCESS ASSOCIATED WITH PENETRATION TO THE GASTROINTESTINAL TRACT DURING TREATMENT USING ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE
- A CASE OF ESOPHAGEAL SMALL CELL CARCINOMA ASSOCIATED WITH HYPERCALCEMIA CAUSING SEVERE ACUTE PANCREATITIS
- A CASE OF RAPIDLY EXPANDING AND INCREASING FOCAL NODULAR HYPERPLASIA
- Exposure to diesel exhaust during fetal period affects behavior and neurotransmitters in male offspring mice
- Prenatal exposure to zinc oxide particles alters monoaminergic neurotransmitter levels in the brain of mouse offspring
- A phase I trial of S-1 with concurrent radiotherapy in patients with locally recurrent rectal cancer