Diesel exhaust (DE) aggravates pathology of delayed-type hypersensitivity (DTH) Induced by methyl-bovine serum albumin (mBSA) in mice
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概要
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Diesel exhaust particles (DEP), a well-known air pollutant, exacerbate type I hypersensitivity conditions, such as asthma and pollen allergy. In this study, we examined the effect of diesel exhaust (DE) exposure on delayed-type hypersensitivity (DTH), a type IV hypersensitivity, induced with methyl-bovine serum albumin (mBSA) in C57BL/6 mice. Mice were exposed to DE containing DEP at a dose of 1.78mg/m^3 in an inhalation chamber for 14 days. On Day 7, DTH mice and DE-exposed DTH mice were injected s.c. with 200μl of 1.25mg/ml mBSA emulsified with CFA in the dorsal region as initial sensitization. On Day 14, mice were injected s.c. into one footpad with 20μl of 10mg/ml mBSA dissolved in PBS as challenge. On Day15, footpad thickness and spleen weight were measured. Significant footpad swelling (%) was observed in DTH mice compared with normal control mice, and this swelling was significantly augmented by DE exposure. The levels, of pro-inflammatory cytokines, including IFN-γ, TNF-α, and IL-6, in DTH mice were significantly higher than in normal mice, and were also further enhanced by DE exposure. DE exposure increased production of IL-17, which enhances local tissue inflammation through up-regulation of pro-inflammatory cytokines, while production of IL-10, which inhibits local tissue inflammation through suppression of immune cell proliferation, was unchanged. No change was observed in the percentage of CD4^+CD25^+Foxp3^+T regulatory (Treg) cells in splenic lymphocytes following DE exposure. IL-6 production was increased by DE, and this would facilitate the differentiation of naive T cells to IL-17-producing Th17 cells, while concomitantly suppressing the competing differentiation pathway to IL-10-producing Treg cells. Our results indicate that DE inhalation may, in part, exacerbate the pathological symptoms of DTH and induction of pro-inflammatory cytokines such as IFN-γ, TNF-α, IL-6 and IL-17.
- 日本トキシコロジー学会の論文
- 2009-10-01
著者
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Kojima Shuji
Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS)
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Tsukimoto Mitsutoshi
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Tsukimoto Mitsutoshi
Fac. Of Pharmaceutical Sciences Tokyo Univ. Of Sci. (tus)
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Tsukimoto Mitsutoshi
東京理科大学 農学部
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Tsukimoto Mitsutoshi
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Takeda Ken
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Oshio Shigeru
Department of Hygiene Chemistry, Ohu University School of Pharmaceutical Sciences
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Oshio Shigeru
Research Center For Health Science Of Nanoparticles Research Institute For Science And Technology To
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Oshio Shigeru
Department Of Biology University Of Tokyo
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OHSHIMA Yasuhiro
Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University
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Sakai Masanobu
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Yamashita Keichiro
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Takemoto Naoya
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Shinkai Yusuke
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science (TU
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Ohshima Yasuhiro
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Takeda K
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Takemoto Naoya
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Shinkai Yusuke
Research Center For Health Science Of Nanoparticles Research Institute For Science And Technology To
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Sakai Masanobu
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Ohshima Yasuhiro
Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University
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Takeda Ken
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science
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Yamashita Keichiro
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Takeda Ken
The Center For Environmental Health Science For The Next Generation Research Institute Far Science And Technology Tokyo University Of Science
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