The Elevation of p53 Protein Level and SOD Activity in the Resident Blood of the Misasa Radon Hot Spring District
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概要
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To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.
- 日本放射線影響学会の論文
- 2005-03-25
著者
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Kojima Shuji
Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS)
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Kojima Shuji
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Shibakura Misako
Departments Of Medical Technology Okayama University Medical School
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YAMAOKA Kiyonori
Departments of Radiological Technology, Okayama University Medical School
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MITSUNOBU Fumihiro
Misasa Medical Center, Okayama University Medical School
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KATAOKA Takahiro
Departments of Radiological Technology, Okayama University Medical School
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HANAMOTO Katsumi
Departments of Radiological Technology, Okayama University Medical School
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TANIZAKI Yoshiro
Misasa Medical Center, Okayama University Medical School
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Kataoka Takahiro
Graduate School Of Health Sciences Okayama University
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Kira S
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Mitsunobu Fumihiro
Misasa Medical Center Okayama University Hospital
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YAMAOKA Kiyonori
Graduate School of Health Sciences, Okayama University
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HANAMOTO Katsumi
Graduate School of Health Sciences, Okayama University
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Hanamoto Katsumi
Graduate School Of Health Sciences Okayama University
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Tanizaki Y
Misasa Medical Center Okayama University Medical School
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Yamaoka Kiyonori
Graduate School Of Health Sciences Okayama University
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Yamaoka Kiyonori
Department of Radiological Technology, Graduate School of Health Sciences, Okayama University
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