Low Dose γ-Rays Activate Immune Functions via Induction of Glutathione and Delay Tumor Growth
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概要
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We examined whether the increase of glutathione level induced by low dose γ-ray irradiation is involved in the appearance of enhanced natural killer (NK) activity and antibody-dependent cellular cytotoxicity (ADCC), leading to delayed tumor growth in Ehrlich solid tumor-bearing mice. NK activity in ICR mouse splenocytes significantly increased from 4h to 6h after whole-body γ-ray irradiation at 0.5Gy, and thereafter decreased almost to the zero-time level by 24h post-irradiation. ADCC also increased significantly in a similar way. Reduced glutathione exogenously added to splenocytes obtained from normal mice enhanced both NK activity and ADCC in a dose-dependent manner. Since immune functions were enhanced through the induction of cellular glutathione after low-dose irradiation, the inhibitory effect of the radiation on tumor growth was then examined in Ehrlich solid tumor-bearing mice. Tumor growth after inoculation was significantly delayed by the radiation. These results suggest that low-dose γ-rays activate immune functions via an induction of glutathione, leading to a delay of tumor growth.
- 日本放射線影響学会の論文
著者
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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NAKAYAMA Keiko
Department of Pediatrics, Wakayama Medical University, School of Medicine
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Nakayama Keiko
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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ISHIDA Hirokazu
Department of Biotechnology and Biomaterial Chemistry, Graduate School of Engineering, Nagoya Univer
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Ishida Hirokazu
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Ishida Hirokazu
Department Of Biotechnology And Biomaterial Chemistry Graduate School Of Engineering Nagoya Universi
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Nakayama Keiko
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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