Suppression by High Glucose Concentration of Insulin Receptor Up-Regulation in Diaphragm and Flexor Digitorum Brevis Muscles from Diabetic KK-CA^y and Streptozotocin-Diabetic Mice

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概要

• 論文の詳細を見る

• The specific binding of insulin to diaphragm and flexor digitorum brevis (FDB) muscles isolated from diabetic KK-CA^y and streptozotocin (STZ)-diabetic ddY mice was investigated under high glucose concentration in vitro. For high-affinity insulin receptor under 2.8 mM glucose, amounts of the receptor and values of dissociation constant (K_d) were greater in both diabetic muscles than in the corresponding normal control muscles, respectively. High glucose concentration up to 16.7 mM reduced both the up-regulation of the receptor and the decrease in the affinity by the diabetic state. These studies strongly suggest that high glucose level in the diabetic state in vivo may suppress the up-regulation of high-affinity insulin receptor in both models of diabetic mice.

• 社団法人日本薬学会の論文

著者

• Kimura Masayasu

  Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin

• KIMURA Ikuko

  Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, Toyama medical and Pharmaceu

• Kimura M

  Health Science Center At San Antonio The University Of Texas

• KOBAYASHI Shinjiro

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University

• NAITOH Takeshi

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace

• NAKADATE Teruo

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace

• Inaba Kazuhiko

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut

• Inaba Kazuhiko

  北陸大学 薬 薬理

• Kimura I

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Kimura Ikuko

  Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic

• Naitoh Takeshi

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut

• Nakadate Teruo

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut

• Kimura M

  Tsumura & Co. Ltd. Ibaraki Jpn

• Kimura Masayasu

  Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine

• Kimura Masayasu

  Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic

• Kimura I

  Department Of Ophthalmology Keio University School Of Medicine

• Kimura Ikuko

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut

• Kobayashi Shinjiro

  Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University

• Kobayashi S

  Kyoritsu Coll. Pharmacy

• Kimura Ikuko

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace

• Kobayashi Shinjiro

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat

• Kimura Masayasu

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti

• Kimura Ikuko

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Kobayashi Shinjiro

  Department of Applied Chemistry, Faculty of Engineering, Kyushu University

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