Structural Components of β-Eudesmol Essential for Its Potentiating Effect on Succinylcholine-Induced Neuromuscular Blockade in Mice
スポンサーリンク
概要
- 論文の詳細を見る
β-Eudesmol, a sesquiterpenoid alcohol isolated from Atractylodes lancea rhizoma, potentiates the neuromuscular blocking effect of succinylcholine (SuCh). The potentiating effect is greater in diabetic muscles than in normal ones. To identify the structural components of β-eudesmol contributing to this action, we examined the potentiating effect of newly synthesized tertiary alcohols related to β-eudesmol in phrenic nerve-diaphragm muscle preparations of normal and alloxan-diabetic mice. Potentiating effects were exhibited by cyclohexylidene derivatives but not by cyclohexanone or cyclohexanol derivatives. The compound 2-(3-hydroxy-3-methylbutyl) cyclohexylidene exhibited a potentiating effect, but 3-(3-hydroxy-3-methylbutyl) cyclohexylidene did not. These results indicate that both the presence of an exo-methylene attached to a cyclohexane ring and the distance between the exo-methylene and the hydroxy group in β-eudesmol are involved in the potentiating effect on SuCh-induced neuromuscular blockade.
- 社団法人日本薬学会の論文
- 1994-09-15
著者
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野中 聡
旭川医科大学耳鼻咽喉科・頭頸部外科学講座
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金井 直樹
北見赤十字病院耳鼻咽喉科・頭頸部外科
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田中 基明
Hanno Research Center Taiho Pharmaceutical
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木村 郁子
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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木村 正康
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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木村 正康
Hscsaテキサス大学
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田中 克尚
Department Of Chemical Pharmacology:faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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野島 浩史
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceu
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野島 浩史
富山医薬大・薬学部・薬品作用
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高村 雄策
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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矢野 伸吾
Hanno Research Center, Taiho Pharmaceutical
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野島 浩史
富山医科薬科大学 薬学部 薬品作用学 研究室
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Inaba Kazuhiko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Inaba Kazuhiko
北陸大学 薬 薬理
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野島 浩史
富山医科薬科大学 薬 薬品作用
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Kimura I
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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Kimura I
Department Of Ophthalmology Keio University School Of Medicine
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矢野 伸吾
Hanno Research Center Taiho Pharmaceutical
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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高村 雄策
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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