Combined Effects of Fangchinoline from Stephania Tetrandra Radix and Formononetin and Calycosin from Astragalus membranaceus Radix on Hyperglycemia and Hypoinsulinemia in Streptozotocin-Diabetic Mice(Pharmacology)
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概要
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The anti-hyperglycemic action of Stephania tetrandra Radix (Stephania) is potentiated by Astragalus membranaceus BUNGE Radix (Astragali) in streptozotocin (STZ)-diabetic ddY mice (Tsutsumi et al., Biol. Pharm. Bull., 26, 313 (2003)). Fangchinoline (0.3-3mg/kg), a main constituent of Stephania, decreased the high level of blood glucose and increased the low level of blood insulin in STZ-diabetic mice. Here, we investigated the combined effects of fangchinoline with isoflavone or isoflavonoid components (formononetin, calycosin and ononin) of Astragali on the hyperglycemia and hypoinsulinemia of STZ-diabetic mice. Formononetin, calycosin and ononin (0.03-0.1mg/kg) alone did not affect the blood glucose or blood insulin level of the diabetic mice. Formononetin and calycosin (0.03-0.1mg/kg) potentiated the anti-hyperglycemic action of fangchinoline (0.3mg/kg), but ononin did not. Formononetin (0.1mg/kg) facilitated the fangchinoline-induced insulin release, and calycosin (0.1mg/kg) also facilitated it, though without statistical significance. In conclusion, the combined effect of fangchinoline with formononetin and calycosin on hyperglycemia in the diabetic mice accounted well for the therapeutic effect of the combination of Stephania with Astragali in Boi-ogi-to. The anti-hyperglycemic action of formononetin appeared to be due to its potentiating action on insulin release. Our strategy for studying combinations of crude drugs and their components in Kampo medicine has uncovered new potentiating effects of formononetin and calycosin on the anti-hyperglycemic action of fangchinoline in STZ-diabetic mice.
- 公益社団法人日本薬学会の論文
- 2007-11-01
著者
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NOMURA Masaaki
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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KOBAYASHI Shinjiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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Nomura Masaaki
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Kobayashi Shinjiro
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat
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Kobayashi Shinjiro
Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University
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Ma Wenjie
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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NISHIOKA-AKAHASHI Tatsuo
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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Nishioka-akahashi Tatsuo
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Takahashi-Nishioka Tatsuo
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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Kobayashi Shinjiro
Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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