The influence of the sennosides on absorption of glycyrrhetic acid in rats

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概要

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• In the course of our clinical studies of Kampo medicine (traditional Japanese medicines), we observed the pharmacokinetic interactions between two herbs. When Onpito (TJ-8117, Kampo medicine) containing licorice and rhubarb was administered orally to human subjects, we observed that the AUC (0-lim) and Cmax of glycyrrhetic acid (GA) in plasma were lower than those treated with other Kampo medicines containing licorice. In this study, we demonstrate the pharmacokinetic interactions of GA derived from glycyrrhizinic acid (GL) in licorice and anthraquinones derived from rhubarb. To our knowledge, this is the first report to investigate the pharmacokinetic interactions between two herbs. When GL was orally co-administrated to rats with a non-effective dose of sennoside A having purgative activity, the AUC (0-lim) and Cmax of GA decreased. In addition, sennoside A did not affect the metabolism of GL by the intestinal bacteria in vitro. In the examination using an in situ loop of rat colon, the remaining ratio of GA rose drastically by the co-administration of sennoside A, sennidin A and rhein. Observed inhibition activity of these anthraquinones on GA absorption depended on the concentration of the components added. The maximum inhibition ratio was approximately 75% by rhein, 60% by sennoside A and 25% by sennidin A. We conclude that the decrease of the pharmacokinetic parameters of GA in human plasma observed in the clinical study of TJ-8117 is attributable to an interactive action of absorption from the intestinal tract by anthraquinones contained in or derived from rhubarb. © 2005 Pharmaceutical Society of Japan.

• 社団法人日本薬学会の論文
• 2005-10-01

著者

• NOMURA Masaaki

  Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan

• Yamaguchi Takuji

  ツムラ中央研究所

• 油田 正樹

  Res. Inst. Of Pharmaceutical Sciences Musashino Univ.

• 油田 正樹

  Medicinal Evaluation Laboratory Tsumura Research Institute

• Nomura Masaaki

  北陸大学 薬学部臨床薬理学

• Nomura Masaaki

  北陸大学 薬学部合成化学

• Kase Y

  Tsumura Research Laboratories Tsumura & Co.

• Kase Yoshio

  ツムラ漢方生薬研究所

• Kase Yoshio

  国立長寿医療センター研究所 老年病研究部

• Kase Yoshio

  Central Research Laboratory Tsumura & Co.

• Aburada M

  Fac. Of Pharmacy Musashino Univ.

• Aburada M

  Tsumura Research Inst. Pharmacology Ibaraki Jpn

• 加瀬 義夫

  津村薬理研究所

• MIZUHARA Yasuharu

  Medicinal Evaluation Laboratory, Tsumura & Co.

• TAKIZAWA Yukiho

  Medicinal Evaluation Laboratory, Tsumura & Co.

• ISHIHARA Kazuhisa

  Medicinal Evaluation Laboratory, Tsumura & Co.

• ASANO Takayuki

  Medicinal Evaluation Laboratory, Tsumura & Co.

• KUSHIDA Hirotaka

  Medicinal Evaluation Laboratory, Tsumura & Co.

• MOROTA Takashi

  Medicinal Evaluation Laboratory, Tsumura & Co.

• KASE Yoshio

  Medicinal Evaluation Laboratory, Tsumura & Co.

• TAKEDA Shuichi

  Medicinal Evaluation Laboratory, Tsumura & Co.

• ABURADA Masaki

  Medicinal Evaluation Laboratory, Tsumura & Co.

• YOKOGAWA Koichi

  Department of Hospital Pharmacy, School of Medicine, Kanazawa University

• Yuzurihara Mitsutoshi

  Tsumura Research Laboratories Tsumura & Co.

• Yuzurihara Mitsutoshi

  Central Research Laboratory Tsumura & Co.

• Yuzurihara Mitsutoshi

  Kampo & Parmacognosy Laboratory Tsumura & Co.

• Nomura Masaaki

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Morota Takashi

  Botanical Raw Materials Research Department Tsumura & Co.

• Morota Takashi

  Botanical Raw Materials Research Dept. Tsumura & Co.

• Asano T

  Medicinal Evaluation Laboratory Tsumura & Co.

• Yanagisawa T

  New Drug Discovery Laboratories R&d Division Tsumura & Co. Ltd.

• 竹田 秀一

  Tsumura & Co. Tsumura Res. Laboratories

• 油田 正樹

  ツムラ研究本部 医薬評価研究所

• Takizawa Yukiho

  Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo

• Kushida Hirotaka

  Medicinal Evaluation Laboratory Tsumura & Co.

• Ishihara Kazuhisa

  Medicinal Evaluation Laboratory Tsumura & Co.

• Ishihara Kazuhisa

  New Drug Discovery Laboratories R&d Division Tsumura & Co. Ltd.

• Mizuhara Yasuharu

  Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo

• Yanagisawa Toshihiko

  Tsumura&co.

• Yanagisawa Toshihiko

  Central Research Laboratories Tsumura & Co.

• Asano Takayuki

  Medicinal Evaluation Laboratory Tsumura & Co.

• Morota Takashi

  Pharmacognosy And Medicinal Resources Research Department Central Research Laboratories Tsumura &

• Kase Yoshio

  ツムラツムラ研究所

• Asano T

  New Drug Discovery Laboratories R&d Division Tsumura & Co. Ltd.

• Yokogawa Koichi

  Department Of Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Aburada Masaki

  Musashino Univ. Tokyo Jpn

• Yokogawa Koichi

  Hospital Pharmacy School Of Medicine Kanazawa Univ.

• Morota Takashi

  Medicinal Evaluation Laboratory Tsumura & Co.

• Noguchi Masamichi

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Nomura Masaaki

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University

• Kushida Hirotaka

  Medicinal Evaluation Laboratory, Tsumura & Co.

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