Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors(Pharmacology)
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概要
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Effects of goshuyuto, a traditional Japanese medicine, on vascular constriction were examined using isolated strips of rat aorta. Goshuyuto (1×10^<-5> to 1×10^<-3>g/ml) caused constriction of aorta strips in a dose-dependent manner. The vasoconstrictive effects of goshuyuto were significantly inhibited by pretreatment with prazosin, an adrenergic α_1 receptor antagonist. The constrictive effects were partially inhibited by pretreatment with BRL15572, a 5-HT_<1D> antagonist, and ketanserin, a 5-HT_<2A> antagonist. However, the constrictive effects were not inhibited by pretreatment with SB216641, a 5-HT_<1B> antagonist, or propranolol, an adrenergic β receptor antagonist. In addition, aqueous extracts of Evodiae Fructus, one of the constituent medicinal herbs of goshuyuto, caused constriction of aorta strips strongly, but aqueous extracts of Zizyphi Fructus, Ginseng Radix, and Zingiberis Rhizoma, the other constituents of goshuyuto, did not have much effect on the vascular response of rat aorta strips. Also, synephrine, which is one of the ingredients of Evodiae Fructus, constricted the rat aorta. These results suggest that goshuyuto constricts rat aorta strips and that the mechanisms involve the adrenergic and/or serotonergic receptors. Also, it may be suggested that Evodiae Fructus and synephrine play the important role in the vasoconstrictive effects of goshuyuto on rat aorta strips.
- 社団法人日本薬学会の論文
- 2009-02-01
著者
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TAKEDA Atsushi
Department of Computer Science, Tohoku Bunka Gakuen University
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
ツムラ漢方生薬研究所
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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加瀬 義夫
津村薬理研究所
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HIBINO Tomoko
Tsumura Research Laboratories, Tsumura & Co.
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YUZURIHARA Mitsutoshi
Tsumura Research Laboratories, Tsumura & Co.
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KASE Yoshio
Tsumura Research Laboratories, Tsumura & Co.
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KANNO Hitomi
Tsumura Research Laboratories, Tsumura & Co.
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Yuzurihara Mitsutoshi
Tsumura Research Laboratories Tsumura & Co.
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Yuzurihara Mitsutoshi
Central Research Laboratory Tsumura & Co.
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Yuzurihara Mitsutoshi
Kampo & Parmacognosy Laboratory Tsumura & Co.
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Kanno Hitomi
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
ツムラツムラ研究所
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Kase Yoshio
Tsumura Research Institute Medicinal Evaluation Laboratory
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Hibino Tomoko
Tsumura Research Laboratories Tsumura & Co.
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Takeda Atsushi
Department Of Medical Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Takeda Atsushi
Department Of Clinical Pathology Showa University Fujigaoka Hospital Showa University School Of Medi
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Yuzurihara Mitsutoshi
Tsumura & Co.
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YUZURIHARA Mitsutoshi
Tsumura Research Laboratories, Tsumura & Co.
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Hibino Tomoko
Tsumura Research Laboratories, Tsumura & Co.
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Takeda Atsushi
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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TAKEDA Atsushi
Department of Clinical Pathology Showa University Fujigaoka Hospital
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Kase Yoshio
Tsumura Research Laboratories, Tsumura & Co.
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Kase Yoshio
Tsumura & Co., Tsumura Research Laboratories
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