Effects of Yokukansan, a Traditional Japanese Medicine, on Memory Disturbance and Behavioral and Psychological Symptoms of Dementia in Thiamine-Deficient Rats

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概要

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• Effects of yokukansan (TJ-54) on memory disturbance and behavioral and psychological symptoms of dementia (BPSD) were investigated in thiamine-deficient (TD) rats which were produced by feeding a TD diet for 37 d. Daily oral administration of TJ-54 (0.5, 1.0 g/kg) ameliorated the memory disturbance, anxiety-like behavior, the increase in aggressive behaviors, the decrease in social behaviors, and several neurological symptoms including opisthotonus observed in TD rats, in a dose-dependent manner. In addition, histopathological examinations showed that TJ-54 inhibited the degeneration of neuronal and astroglial cells in the brain stem, hippocampus and cortex in TD rats. Microdialysis experiments showed that TJ-54 inhibited extracellular glutamate rise in the ventral posterior medial thalamus in TD rats. These results suggest that TJ-54 possesses the preventive or progress inhibitive effect against the development of memory disturbance and BPSD-like behaviors induced by the degeneration of neuronal and astroglial cells resulting from TD. TJ-54 may inhibit glutamate-mediated excitotoxicity as one of mechanisms.

著者

• TAKEDA Shuichi

  Tsumura and Co., Pharmacology Research Department, R&D Division

• IKARASHI Yasushi

  Tsumura Research Institute Medical Evaluation Laboratory

• IIZUKA Seiichi

  Tsumura Research Institute, Tsumura & Co.

• Kanno Hitomi

  Tsumura Research Laboratories Tsumura & Co.

• Imamura Sachiko

  Tsumura Research Laboratories, Tsumura & Co., Japan

• Iizuka Seiichi

  Central Laboratories Tsumura & Co.

• Kase Yoshio

  Tsumura Research Institute Medicinal Evaluation Laboratory

• Imamura Sachiko

  Research Division Tsumura & Co.

• Yuzurihara Mitsutoshi

  Tsumura & Co.

• Yamaguchi Takuji

  Tsumura Research Laboratories, Tsumura & Co.

• Sekiguchi Kyoji

  Tsumura Research Laboratories, Tsumura & Co.

• Kawakami Zenji

  Tsumura Research Laboratories, Tsumura & Co.

• Takeda Shuichi

  Tsumura & Co. Tsumura Research Laboratories

• YUZURIHARA Mitsutoshi

  Tsumura Research Laboratories, Tsumura & Co.

• Iizuka Seiichi

  Tsumura Research Laboratories, Tsumura & Co.

• Ikarashi Yasushi

  Tsumura Research Laboratories, Tsumura & Co.

• Imamura Sachiko

  Tsumura Research Laboratories, Tsumura & Co.

• Sekiguchi Kyoji

  Tsumura Research Laboratories, Tsumura & Co.

• Kawakami Zenji

  Tsumura Research Laboratories, Tsumura & Co.

• Kase Yoshio

  Tsumura Research Laboratories, Tsumura & Co.

• Kase Yoshio

  Tsumura & Co., Tsumura Research Laboratories

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