Effect of the traditional Japanese medicine Sairei-to on edema in mouse anti-GBM nephritis
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概要
- 論文の詳細を見る
柴苓湯(TJ-114)の浮腫に対する作用について抗糸球体基底膜(GBM)腎炎マウスを用いて検討した。柴苓湯(0.38-1.5 g/kg/day)およびフロセミド(50mg/kg/day)を抗GBM抗血清投与6日目から4日間連続経口投与した。血漿量(PV)はEvans blue色素法にて,細胞外液量(ECFV)はKBr法にてそれぞれ測定し,組織間液量(ISFV)を算出した。腎炎対照群では正常群に比し,蛋白尿と尿中ナトリウム排泄の低下が認められ,PV,ECFV,ISFVがいずれも増加した。一方,柴苓湯は蛋白排泄とPVを変化させずにECFVおよびISFVを用量依存的に低下させた。フロセミド投与群にも同様の結果が認められた。以上の結果より,柴苓湯はネフローゼ浮腫に有用であることが示唆された。
- 2004-06-20
著者
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藤塚 直樹
株式会社ツムラ 研究開発本部 中央研究所 薬理研究部 育薬研究2グループ
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藤塚 直樹
株式会社ツムラ研究本部医薬評価研究所薬効評価研究4グループ
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TADA Kinji
Tsumura Research Institute Medicinal Evaluation Laboratory
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KOBAYASHI Mii
Pharmacognosy & Medicinal Resources Laboratory
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MAKINO Bunsho
Pharmacognosy & Medicinal Resources Laboratory
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ENDO Yuichi
Pharmacognosy & Medicinal Resources Laboratory
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Tada K
Tsumura Research Institute Medicinal Evaluation Laboratory
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Kase Yoshio
Tsumura Research Institute Medicinal Evaluation Laboratory
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Makino Bunsho
Pharmacognosy & Medicinal Resources Laboratory
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Kobayashi Mii
Pharmacognosy & Medicinal Resources Laboratory
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Endo Yuichi
Pharmacognosy & Medicinal Resources Laboratory
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Aburada Masaki
Tsumura Co. Ltd.
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Fujitsuka N
Tsumura Research Institute Medicinal Evaluation Laboratory
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Takeda Shuichi
Tsumura Research Institute Medicinal Evaluation Laboratory
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Takeda Shuichi
Tsumura & Co. Tsumura Research Laboratories
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Kase Yoshio
Tsumura & Co., Tsumura Research Laboratories
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