Anti-hyperlipidemic and Anti-atherosclerotic Actions of Shosaikoto (Kampo Medicine)
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the anti-atherosclerotic action shown by Shosaikoto, a Kampo medicine, using hypercholesterolemic mice. Oral administration of Shosaikoto significantly suppressed the elevation of serum cholesterol in C57BL/6 mice fed a 1.25% cholesterol-enriched diet for four weeks and improved the T cell ratio in peripheral blood, which decreased with the increase of the serum cholesterol level. In addition, Shosaikoto reduced the accumulation of cholesteryl oleate, which alters macrophages into foam cells, after the treatment of macrophages with oxidized or acetylated low density lipoprotein (LDL). Enzymatic study revealed that the treatment of macrophages with oxidized LDL enhanced acyl-coenzyme A : cholesterol acyltransferase (ACAT) activity and markedly reduced neutral cholesteryl ester hydrolase (NCEase) activity. Shosaikoto treatment prevented a decrease in the NCEase activity, however due to the oxidized LDL treatment, although it slightly augmented ACAT activity. Thus, Shosaikoto, which is known to modulate the immune system, improves macrophage and lymphocyte functions diminished by hypercholesterolemia, resulting in an anti-atherosclerotic action.
- 公益社団法人日本薬学会の論文
- 1996-09-15
著者
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Inoue Makoto
Department of Pediatrics, Shimane Medical University
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Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
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ABURADA Masaki
Tsumura Research Institute Medical Evaluation Laboratory
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Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Shen Yirong
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Y
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Aburada Masaki
Tsumura Co. Ltd.
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SHEN Yi
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University
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NAGATSU Yuko
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University
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Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Shen Yi
Department Of Pathophysiology Chongqing Medical University
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Nagatsu Yuko
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
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