STRUCTURE-ACTIVITY STUDIES OF SOME OLEANANE TRITERPENOID GLYCOSIDES AND THEIR RELATED COMPOUNDS FROM THE LEAVES OF TETRAPANAX PAPYRIFERUM ON ANTI-INFLAMMATORY ACTIVITIES
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概要
- 論文の詳細を見る
The anti-inflammatory activities of oleanane triterpenoid glycosides, papyrioside L-IIa, L-IIb, L-IIc and L-IId, extracted from Tetrapanax papyriferum (Araliaceae), and their aglycones, papyriogenin A and C and propapyriogenin A_1 and A_2,were investigated by using the carrageenin-induced edema and the cotton pellet granuloma tests in mice. Of these compounds, papyriogenin A and C (30 mg/kg p.o.) manifested in these tests almost the same potency as prednisolone (25 mg/kg p.o.). The structure-activity relationships of these and related triterpenes have been investigated. This takes into account particularly variation in the oxygen function and the molecular conformation. We have found that the anti-inflammatory activity of these triterpenes was favoured when the molecules tended to take a planar conformation ; this was induced by the heteroanulardiene group between C and D ring.
- 公益社団法人日本薬学会の論文
著者
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Ogihara Yukio
Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Ogihara Y
Nagoya City Univ. Nagoya Jpn
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Amagaya Sakae
Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University
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SUGISHITA ETSUKO
Faculty of Pharmaceutical Sciences, Nagoya City University
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Sugishita Etsuko
Faculty Of Pharmaceutical Sciences Nagoya City University
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Sugishita Etsuko
Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University
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Amagaya Sakae
Department of Kampo Pharmaceutical Sciences, Nihon Pharmaceutical University
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