STUDIES ON THE MECHANISM OF ANTI-INFLAMMATORY ACTIVITIES OF PAPYRIOGENIN A AND PAPYRIOGENIN C

スポンサーリンク

概要

• 論文の詳細を見る

• The mechanism of anti-inflammatory action of papyriogenin A and C, obtained from Tetrapanax papyriferum, were investigated by the following methods; the cotton pellet granuloma test in normal and adrenalectomized rats, the blockade by anti-glucocortucoids of vascular permeability caused by serotonin in mice and the competition on 5β-reduction of steroidal compounds. The anti-inflammatory activity was observed in the decreasing order; papyriogenin C>papyriogenin A on the carrageenin-induced paw edema in mice, as reported in our previous paper.^<1)> In a serotonin-induced paw edema, pretreatment with progesterone (50,100 and 200 mg/kg) blocked completely the anti-inflammatory effects of papyriogenin A or C at 10 and 50 mg/kg. When actinomycin D (l and 2 mg/kg) or cycloheximide (6 mg/kg) was given twice, simultaneously with papyriogenin A or C, during the latent period for the manifestation of the anti-inflammatory effect, the anti-inflammatory effects of papyriogenin A and C were blocked completely by s.c. administration. The effects of papyriogenin A or C, 30 mg/kg p.o., on the cotton pellet granuloma test in adrenalectomized rats were similar to those of normal rats. On the other hand, the competitive effects of papyriogenin A and C on 5β-reduction of testosterone and cortisol were recognized to be significant. These activities of papyriogenin A and C are explained by their steroidal actions in the target cell and their competitive effects in endogenous corticoid metabolism in liver.

• 公益社団法人日本薬学会の論文

著者

• Amagaya Sakae

  Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University

• Sugishita Etsuko

  Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University

• OGIHARA YUKI0

  Department of Pharmacognosy, Faculty cf Pharmaceutical Sciences, Nagoya City University

• Ogihara Yuki0

  Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University

• Amagaya Sakae

  Department of Kampo Pharmaceutical Sciences, Nihon Pharmaceutical University

関連論文

• Choleretic Actions of Iridoid Compounds
• STUDIES ON THE COMBINATION OF GLYCYRRHIZAE RADIX IN SHAKUYAKUKANZO-TO
• STRUCTURE-ACTIVITY STUDIES OF SOME OLEANANE TRITERPENOID GLYCOSIDES AND THEIR RELATED COMPOUNDS FROM THE LEAVES OF TETRAPANAX PAPYRIFERUM ON ANTI-INFLAMMATORY ACTIVITIES
• ANTI-INFLAMMATORY TESTING METHODS : COMPARATIVE EVALUATION OF MICE AND RATS
• STUDIES ON THE MECHANISM OF ANTI-INFLAMMATORY ACTIVITIES OF PAPYRIOGENIN A AND PAPYRIOGENIN C
• A Naturally Occurring Rexinoid, Honokiol, Can Serve as a Regulator of Various Retinoid X Receptor Heterodimers

スポンサーリンク