STUDIES ON THE MECHANISM OF ANTI-INFLAMMATORY ACTIVITIES OF PAPYRIOGENIN A AND PAPYRIOGENIN C
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概要
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The mechanism of anti-inflammatory action of papyriogenin A and C, obtained from Tetrapanax papyriferum, were investigated by the following methods; the cotton pellet granuloma test in normal and adrenalectomized rats, the blockade by anti-glucocortucoids of vascular permeability caused by serotonin in mice and the competition on 5β-reduction of steroidal compounds. The anti-inflammatory activity was observed in the decreasing order; papyriogenin C>papyriogenin A on the carrageenin-induced paw edema in mice, as reported in our previous paper.^<1)> In a serotonin-induced paw edema, pretreatment with progesterone (50,100 and 200 mg/kg) blocked completely the anti-inflammatory effects of papyriogenin A or C at 10 and 50 mg/kg. When actinomycin D (l and 2 mg/kg) or cycloheximide (6 mg/kg) was given twice, simultaneously with papyriogenin A or C, during the latent period for the manifestation of the anti-inflammatory effect, the anti-inflammatory effects of papyriogenin A and C were blocked completely by s.c. administration. The effects of papyriogenin A or C, 30 mg/kg p.o., on the cotton pellet granuloma test in adrenalectomized rats were similar to those of normal rats. On the other hand, the competitive effects of papyriogenin A and C on 5β-reduction of testosterone and cortisol were recognized to be significant. These activities of papyriogenin A and C are explained by their steroidal actions in the target cell and their competitive effects in endogenous corticoid metabolism in liver.
- 公益社団法人日本薬学会の論文
著者
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Amagaya Sakae
Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University
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Sugishita Etsuko
Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University
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OGIHARA YUKI0
Department of Pharmacognosy, Faculty cf Pharmaceutical Sciences, Nagoya City University
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Ogihara Yuki0
Department Of Pharmacognosy Faculty Cf Pharmaceutical Sciences Nagoya City University
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Amagaya Sakae
Department of Kampo Pharmaceutical Sciences, Nihon Pharmaceutical University
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