Effects of Kampo-hozais on the Induction of Oral Tolerance to Ovalbumin in Mice
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概要
- 論文の詳細を見る
We studied here the effect of 3 kinds of kampo-hozais (Shofu-san, Ji-zuso-ippo and Unsei-in) on the induction of oral tolerance to ovalbumin (OVA) in C3H/HeN mice by measuring serum levels of OVA-specific antibodies. Oral tolerance was induced by a single administation of OVA (2 or 20 mg, p.o.) 7d before the immunization.Among these kampo-hozais, mice administered Ji-zuso-ippo for 7d before feeding of 2 mg OVA had significantly lower levels of anti-OVA IgG and IgG1,and further, Ji-zuso-ippo tended to reduce anti-OVA Igs in 20 mg OVA-fed mice, whereas Ji-zuso-ippo did not alter anti-OVA Igs in non-OVA-fed mice. Unsei-in also slightly augmented the suppression of anti-OVA IgG and IgG1 ; however, this lowering action of Unsi-in should be due to its immunosuppressive effect. Shofu-san did not alter these anti-OVA Ig levels in serum. These results suggested that Ji-zuso-ippo could augment the induction of oral tolerance.
- 公益社団法人日本薬学会の論文
- 1999-04-15
著者
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Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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NOSE Mitsuhiko
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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NOSE Mitsuhiko
Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City Uni
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Nose M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Sakushima Jun-ichiro
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Ogihara Y
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Ogihara Yukiko
Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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