Effect of Hachimi-jio-gan on Immunoglobulin A Producing Cells in Peyer's Patch by Oral Administration
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概要
- 論文の詳細を見る
We investigated here the effect of Hachimi-jio-gan (HJ), a Japanese and Chinese herbal medicine, on immunoglobulin A (IgA) producing cells in Peyer's patch. The oral administration of HJ (0.1,0.2,1.0 g/kg for 2 d) enhanced the IgA producing cells almost 2-fold compared with the control group on days 4 and 5 after the administration. Furthermore, HJ augmented antigen-specific IgA (anti-SRBC IgA) production. These results suggested that HJ acted as a polyclonal B cell activator. To characterize its active ingredients, HJ was fractionated by ethanol precipitation. The crude polysaccharide fraction (EP fraction) showed the ability to augment IgA production, but low molecular weight fraction (ES fraction) did not. These results suggest that the crude polysaccharide fraction might be responsible for the augmentation of IgA production by HJ.
- 公益社団法人日本薬学会の論文
- 1997-11-15
著者
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Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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NOSE Mitsuhiko
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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NOSE Mitsuhiko
Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City Uni
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Nose M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Sakushima Jun-ichiro
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Ogihara Y
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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