SHOSAIKOTO (KAMPO MEDICINE) PROTECTS MACROPHAGE FUNCTION FROM SUPPRESSION BY HYPERCHOLESTEROLEMIA
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概要
- 論文の詳細を見る
The feeding of cholesterol-enriched diet for 2 weeks was enough to reduce nitric oxide (NO), prostaglandin E_2 (PGE_2) and interleukin-1 (IL-1) productions in thioglycollate-ellicited murine macrophages. Although not showing anti-hypercholesterolemic action against ICR mice, Shosaikoto, a Kampo medicine, partially prevented the reduction of NO and IL-1 productions induced by the feeding of cholesterol-enriched diet, and completely released the reduction of PGE_2 production. These data suggest that the malfunction of macrophage induced by hypercholesterolemia may contribute to early atherogenesis and that Shosaikoto retains macrophage function to preveny the development of atherosclerosis, even though serum cholesterol is markedly increased.
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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Inoue Makoto
Department of Pediatrics, Shimane Medical University
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Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
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Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Shen Yirong
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Y
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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SHEN Yi
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University
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Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Shen Yi
Department Of Pathophysiology Chongqing Medical University
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