Restorative Effect of Shosaikoto (Kampo Medicine) on Diminution of Nitric Oxide Synthesis in Murine Peritoneal Macrophages induced by Hyperocholesterolemia
スポンサーリンク
概要
- 論文の詳細を見る
Macrophages play important roles both in immune response and in lipid metabolism and contribute to the development of atherosclerosis. To clarify the mechanism by which Shosaikoto, a Kampo medicine, shows anti-atherosclerotic action, we studied its effect on macrophage function. The production of nitric oxide (NO), prostaglandin E_2 and interleukin 1 by macrophages in mice was reduced by feeding of a cholesterol-enriched diet, and the reduced production was observed 1 week after the beginning of cholesterol feeding. Furthermore, although oxidized low density lipoprotein (LDL) and lysophosphatidylcholine (LPC) reduced NO production, macrophages prepared from mice treated with Shosaikoto at a dose of 1.2 g/kg/d restored the reduced NO production by them as well as by hypercholesterolemia. When the content of LPC was measured, no difference was observed between mice fed a cholesterol-enriched diet in the presence or absence of Shosaikoto treatment, suggesting that the restorative effect of Shosaikoto is not due to the inhibition of LPC production or accumulation. Conclusively, Shosaikoto prevents the modification of macrophage function induced by atherogenic factors, which is probably lined to its displayed anti-atherosclerotic action.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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Inoue Makoto
Department of Pediatrics, Shimane Medical University
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Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
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Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Shen Yirong
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Y
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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SHEN Yi
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University
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Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Shen Yi
Department Of Pathophysiology Chongqing Medical University
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