Induction of Apoptotic Cell Death in HL-60 Cells by Acteoside, A Phenylpropanoid Glycoside
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概要
- 論文の詳細を見る
Acteoside, a phenylpropanoid glycoside with anti-oxidative activity, induced cell death in promyelocytic leukemia HL-60 cells with an IC_<50> value of 26.7μM. Analysis of extracted DNA on agarose gel electrophoresis revealed that aceteoside induced the internucleosomal breakdown of chromatin DNA characteristic of apoptosis.Apoptosis-specific DNA fragmentation was clearly detectable 4h after treatment with acteoside and was indepedent of the cell cycle phase. These data indicate that acteoside induces apoptosis in HL-60 cells.
- 社団法人日本薬学会の論文
- 1998-01-15
著者
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Inoue Makoto
Department of Pediatrics, Shimane Medical University
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SARACOGLU Iclal
Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University
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Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
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Saracoglu Iclal
Department Of Pharmacognosy Faculty Of Pharmacy Hacettepe University
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Saracoglu Iclal
トルコ
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Ogihara Y
Nihon Pharmaceutical University
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Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Ogihara Yukio
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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SAKUMA Zentaro
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University
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Sakuma Zentaro
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
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Saracoglu I
Department Of Pharmacognosy Faculty Of Pharmacy Hacettepe University
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Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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