Studies on Chemical Modification of Monensin IX. Synthesis of 26-Substituted Monensins and Their Na^+Ion Transport Activity
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概要
- 論文の詳細を見る
The C-26 modified monensin derivatives, 26-O-benzoylmonensin (3), 26-O-benzylmonensin (4) and 26-phenylaminomonensin (5) were prepared from monensin (1). Na^+ion transport activity through biological membrane and antibacterial activity of 3-5 were evaluated and compared with the activities reported for a 26-phenylurethane derivative (2). Among these compounds, 5 showed the largest Na^+ion transport and antibacterial activities. In these compounds, the formation of head-to-tail hydrogen bonds was suggested to be an important factor for Na^+ion transport and antibacterial activities.
- 公益社団法人日本薬学会の論文
- 2001-06-01
著者
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OGIHARA Yukio
Nihon Pharmaceutical University
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永津 明人
名市大院薬
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Nagatsu A
Nagoya City Univ. Nagoya Jpn
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Nagatsu Akito
Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Y
Nihon Pharmaceutical University
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Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Faculty Of Pharmacy Meijo Universitv
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Ogihara Yukio
Faculty Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Graduate School Of Pharmaceutical Sciences Nagoya City University
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MIZUKAMI Hajime
Faculty of Pharmaceutical Sciences, Nagoya City University
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SAKAKIBARA Jinsaku
Faculty of Pharmacy, Meijo University
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Mizukami Hajime
Department Of Legal Medicine Asahikawa Medical College
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TANAKA Rie
Faculty of Pharmaceutical Sciences, Nagoya City University
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Sakakibara J
Faculty Of Pharmaceutical Sciences Nagoya City University
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Sakakibara Jinsaku
Faculty Of Pharmaceutical Sciences Nagoya City University
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Mizukami Hajime
Faculty Of Pharmaceutical Sciences Nagoya City University
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Tanaka Rie
Faculty Of Pharmaceutical Sciences Nagoya City University
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Mizukami H
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
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Mizukami Hajime
Faculty Of Pharmaceutical Science Nagoya City University
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