Synthesis of Phenoxyacetic Acid Derivatives as Highly Potent Antagonists of Gastrin/Cholecystokinin-B Receptors
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概要
- 論文の詳細を見る
A novel series of phenoxyacetic acid derivatives was synthesized based on considerations of the three-dimensional structural similarity of YM022 and RP72540. The gastrin/cholecystokinin (CCK)-B and CCK-A receptor antagonist activities of these compounds were evaluated by investigation of their affinities for human gastrin/CCK-B receptors and human CCK-A receptors, respectively. It was found that N-methyl-N-phenyl-2-[2-[N-(N-methyl-N-phenyl-carbamoylmethyl)-N-[2-[3-(3-methylphenyl)ureido]acetyl]amino]phenoxy]acetamide (20k, DZ-3514) exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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高石 喜久
徳島大院薬
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Takeda Y
Fac. Of Integrated Arts And Sciences Univ. Of Tokushima
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Takeda Y
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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Honda Y
Kumamoto Univ. Kumamoto Jpn
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Honda Yuko
Institute For Solid State Physics The University Of Tokyo
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Honda Yuko
Dept. Biol. Sci. Ehime Univ.
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Ogihara Y
Nihon Pharmaceutical University
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Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Yukio
Faculty Of Pharmacy Meijo Universitv
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Ogihara Yukio
Graduate School Of Pharmaceutical Sciences Nagoya City University
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細上 徹
第一製薬株式会社 (東京研究開発センター) 探索第三研究所
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細上 徹
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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TAKEDA Yasuyuki
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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KAWAGOE Keiichi
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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YOKOMIZO Aki
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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YOKOMIZO Yoshihiro
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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HOSOKAMI Toru
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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OGIHARA Yoshiyasu
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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HONDA Yuko
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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YOKOHAMA Shuichi
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.,
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Yokomizo Yoshihiro
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Yokomizo Aki
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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細上 徹
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Kawada K
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Yokohama S
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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