Inhibition of Theophylline Metabolism by Aciclovir
スポンサーリンク
概要
- 論文の詳細を見る
We report a case of side effects caused by the increase in plasma theophylline concentration after coadministration of aciclovir had been started during theophylline therapy. Interaction between theophylline and aciclovir has not previously been reported. Therefore, a study of the pharmacokinetic and metabolic interactions between theophylline and aciclovir was carried out in five healthy male volunteers. All subjects received a single oral dose of 320 mg theophylline (aminophylline, 400 mg) after they had taken oral aciclovir 800 mg five times daily for two consecutive days. The area under the curve from 0 to infinity of theophylline (AUC_<0-∞>) after coadministration of aciclovir was increased from 189.9±18.2 to 274.9±34.3 μg・h/ml (p<0.01), and total body clearance was decreased from 28.4±2.9 to 19.8±2.5 ml/h/kg (p<0.01). Further, there was a significant increase in urinary theophylline and decreases in urinary 1,3-dimethyluric acid and 1-methyluric acid after coadministration of aciclovir. The decrease in total body clearance is likely to have resulted from inhibition of metabolism via the oxidation pathway.The results indicated that with aciclovir therapy lower doses of theophylline might be necessary and careful monitoring of plasma concentrations was essential.
- 公益社団法人日本薬学会の論文
- 1996-12-15
著者
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Takeda Y
Fac. Of Integrated Arts And Sciences Univ. Of Tokushima
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Konishi Toshio
Pharmacy:chugoku Rosai Hospital
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Konishi Toshio
Department Of Hospital Pharmacy Chugoku Rosai Hospital
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Konishi Toshio
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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FUKUZAWA Masataka
Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University
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Fukuhara Shinji
Department Of Hospital Pharmacy Chugoku Rosai General Hospital
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TSUKIAI Satsuki
Department of Pharmaceutical Services, Hiroshima University Hospital
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Konishi T
Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn
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Maeda Y
Chugoku‐rosai Hospital Hiroshima Jpn
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Maeda Yorinobu
Pharmacy:chugoku Rosai Hospital
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Maeda Yorinobu
Department Of Pharmacy Chugoku Rosai Hospital:department Of Surgery Chugoku Rosai Hospital
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Maeda Yorinobu
Department Of Chugoku Rosai Hospital Pharmacy Surgery Medical Technology
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OMODA Kei
Department of Pharmacy, Chugoku Rousai General Hospital
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Omoda K
Department Of Hospital Pharmacy Chugoku Rosai General Hospital
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Tsukiai S
Department Of Hospital Pharmacy Chugoku Rosai General Hospital
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TAKEDA Yoshiaki
Department of Hospital Pharmacy Chugoku Rosai General Hospital
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OHUNE Terumasa
Internal Medicine Chugoku Rosai General Hospital
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TSUYA Takafumi
Internal Medicine Chugoku Rosai General Hospital
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Tsukiai Satsuki
Department Of Hospital Pharmacy Chugoku Rosai General Hospital
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Fukuzawa Masataka
Pharmacy:chugoku Rosai Hospital
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Fukuzawa Masataka
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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