Cytotoxic Screening of Medicinal and Edible Plants in Okinawa, Japan, and Identification of the Main Toxic Constituent of Rhodea japonica (Omoto)(Organic Chemistry)

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概要

• 論文の詳細を見る

• The cytotoxic activity of ethanol extracts from 53 parts of 36 species of medicinal and edible plants cultivated in Okinawa was measured by using K562 human leukemia cells by a flow cytometric method. Two extracts from Rhodea japonica and Hypericum chinense were cytotoxic at a concentration of 10μg/ml. The main cytotoxic constituent of Rhodea japonica was isolated and identified to be rhodexin A, which has been isolated as a cardetonic agent of the plant. The IC_<50> value for rhodexin A against the growth of K562 cells was 19 nM, this activity being much stronger than that of ouabain (IC_<50>, 60 nM).

• 社団法人日本農芸化学会の論文
• 2003-06-23

著者

• 高石 喜久

  徳島大院薬

• Masuda Tomomi

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co.ltd.

• Takeda Yoshio

  Faculty of Pharmacy, Yasuda Womens University

• Takeda Y

  Fac. Of Integrated Arts And Sciences Univ. Of Tokushima

• Takeda Y

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Masuda T

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Masuda Toshiya

  Faculty Of Integrated Arts And Sciences University Of Tokushima

• Masuda Toshiya

  Faculty Of Human Life Science Osaka City University

• Takeda Y

  Faculty Of Engineering Mie University

• Nakamoto K

  Chiba Univ. Chiba Jpn

• Masuda Toshiya

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• OYAMA Yasuo

  Faculty of Integrated Arts and Sciences, University of Tokushima

• YAMAMOTO Natsuko

  Faculty of Integrated Arts and Sciences, University of Tokushima

• UMEBAYASHI Chisato

  Faculty of Integrated Arts and Sciences, University of Tokushima

• NAKAO Hiromi

  Faculty of Integrated Arts and Sciences, University of Tokushima

• TOI Yukiko

  Faculty of Integrated Arts and Sciences, University of Tokushima

• NAKAMOTO Katsuo

  Nakazen Inc.

• KUNINAGA Hideki

  Nakazen Inc.

• NISHIZATO Yukari

  Nakazen Inc.

• NONAKA Akira

  Nakazen Inc.

• Takeda Yoshio

  Faculty Of General Arts And Sciences The Tokushima University

• Yamamoto N

  Calpis Co. Ltd. Kanagawa Jpn

• Toi Yukiko

  Faculty Of Integrated Arts And Sciences University Of Tokushima

• Oyama Y

  Univ. Tokushima Tokushima Jpn

• Oyama Yasuo

  Laboratory Of Cellular Signalling Faculty Of Integrated Arts And Sciences The University Of Tokushim

• Oyama Yasuo

  Laboratories Of Cellular Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences

• Nakao Hiromi

  Laboratories Of Cell Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences The

• Nakao Hiromi

  Faculty Of Agriculture Kyushu University Japan

• Oyama Y

  Laboratories Of Cell Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences The

• Yamamoto N

  Faculty Of Integrated Arts And Sciences University Of Tokushima

• Umebayashi Chisato

  Laboratories Of Cell Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences The

• Oyama Yasuo

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Umebayashi C

  Faculty of Integrated Arts and Sciences, University of Tokushima

• Nakao H

  Faculty of Integrated Arts and Sciences, University of Tokushima

• Toi Y

  Faculty of Integrated Arts and Sciences, University of Tokushima

• Nakamoto K

  Nakazen Inc.

• Kuninaga H

  Nakazen Inc.

• Nishizato Y

  Nakazen Inc.

• Nonaka A

  Nakazen Inc.

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