Tyrosinase Inhibitory Activity of Ethanol Extracts from Medicinal and Edible Plants Cultivated in Okinawa and Identification of a Water-Soluble Inhibitor from the Leaves of Nandina domestica
スポンサーリンク
概要
- 論文の詳細を見る
Previously we found that replacement of seven amino acid residues in a loop region markedly shifted the coenzyme specificity of malate dehydrogenase from NAD(H) toward NADP(H). In the present study, we replaced the seven amino acid residues in the corresponding region of an NAD(H)-dependent lactate dehydrogenase with those of NADP(H)-dependent malate dehydrogenase, and examined the coenzyme specificity of the resulting mutant enzyme. Coenzyme specificity was significantly shifted by 399-fold toward NADPH when kcat⁄Kmcoenzyme was used as the measure of coenzyme specificity. The effect of the replacements on coenzyme specificity is discussed based on in silico simulation of the three-dimensional structure of the lactate dehydrogenase mutant.
- 社団法人 日本農芸化学会の論文
- 2007-09-23
著者
-
Takeda Yoshio
Faculty of Pharmacy, Yasuda Womens University
-
Masuda Toshiya
Faculty Of Integrated Arts And Sciences University Of Tokushima
-
Masuda Toshiya
Faculty Of Human Life Science Osaka City University
-
YONEMORI Shigetomo
Tropical Biosphere Research Center, University of Ryukyus
-
NAKAMOTO Katsuo
Nakazen Inc.
-
KUNINAGA Hideki
Nakazen Inc.
-
Takeda Yoshio
Faculty Of General Arts And Sciences The Tokushima University
-
FUJITA Nao
Faculty of Integrated Arts and Sciences, University of Tokushima
-
ODAKA Yuka
Faculty of Integrated Arts and Sciences, University of Tokushima
-
Odaka Yuka
Faculty Of Integrated Arts And Sciences University Of Tokushima
-
Fujita Nao
Faculty Of Integrated Arts And Sciences University Of Tokushima
-
Takeda Yoshio
Faculty Of Integrated Arts And Sciences University Of Tokushima
-
Yonemori Shigetomo
Tropical Biosphere Research Center University Of Ryukyus
-
Yonemori Shigetomo
Tropical Bioshere Research Center University Of Ryukyus Japan
-
Tomita Takeo
Faculty of Integrated Arts and Sciences, University of Tokushima
-
Kuzuyama Tomohisa
Faculty of Integrated Arts and Sciences, University of Tokushima
-
Nishiyama Makoto
Faculty of Integrated Arts and Sciences, University of Tokushima
関連論文
- Structural Revisions of Blumenol C Glucoside and Byzantionoside B
- Tricalysionoside A, a Megastigmane Gentiobioside, Sulfatricalysines A—F, and Tricalysiosides X—Z, ent-Kaurane Glucosides, from the Leaves of Tricalysia dubia
- Constituents in Watercress : Inhibitors of Histamine Release from RBL-2H3 Cells Induced by Antigen Stimulation
- Reinvestigation of the Absolute Stereochemistry of Megastigmane Glucoside, Icariside B5
- A New Synthesis of 3-Oxosapriparaquinone, a Diterpene from Salvia prionitis HANCE (Libiatae)
- Synthesis of Pygmaeocine E, a Linear Abietane Diterpene from Pygmaeopremna herbacea (ROXB.) MOLDENKE
- Synthesis of 6-Methoxy-1,1,10-trimethyl-1,2,3,4-tetrahydroanthracene, a Synthetic Intermediate of a Linear Abietane Diterpene, Umbrosone
- Synthesis of 3-Oxosapriparaquinone, a Diterpene from Salvia prionitis Hance
- Skeletal Rearrangement of the Dehydroabietic Acid Derivative
- A Novel Immunosuppressant, ISP-I, of Isaria sinclairii
- Diterpenoid Constituents of Rabdosia inflexa : Structure Elucidation of Two New Diterpenoids, Inflexanins A and B(Pharmacognosy,Chemical)
- Effect of Olmesartan on Oxidative Stress in Hemodialysis Patients
- Oxidation and Carboxy Methyl Lysine-Modification of Albumin : Possible Involvement in the Progression of Oxidative Stress in Hemodialysis Patients
- A new phenolic glucoside from an Uzbek medicinal plant, Origanum tyttanthum
- A New Megastigmane Glucoside from Phlomis spinidens
- Molecular Cloning, Functional Expression and Characterization of d-Limonene Synthase from Schizonepeta tenuifolia
- Radical and Superoxide Scavenging Activities of Matairesinol and Oxidized Matairesinol
- Lignan and neolignan glucosides, and tachioside 2'-O-4"-O-methylgallate from the leaves of Glochidion rubrum
- Glycosidic constituents of the leaves of an Okinawan Leguminosae plant, Derris trifoliata Lour
- Rearranged ent-kauranes from the stems of Tricalysia dubia and their biological activities
- Tareciliosides A-G : Cycloartane Glycosides from Leaves of Tarenna gracilipes (HAY.) OHWI
- Bridelioside, a new lignan glycoside from Bridelia glauca Bl. f. balansae (Tucht.) Hatusima
- Tricalysiosides P-U : Ent-kaurane Glucosides and a Labdane Glucoside from Leaves of Tricalysia dubia OHWI
- Chemical constituents of an Uzbek medicinal plant, Perovskia scrophularifolia
- Tricalysiolide G, and Tricalysiols A and B : rearranged ent-Kaurane-Type and ent-Kaurane-Type Diterpenoids from the Leaves of Tricalysia dubia (Lindl.) Ohwi
- Radical-Scavenging Activities of New Megastigmane Glucosides from Macaranga tanarius (L.) MULL.-ARG
- Staphylionosides A-K : Megastigmane Glucosides from the Leaves of Staphylea bumalda DC.
- Indole alkaloids from Rheum maximowiczii
- Terpenic and Phenolic Glycosides from Leaves of Breynia officinalis HEMSL.
- Glochidiolide, Isoglochidiolide, Acuminaminoside, and Glochidacuminosides A-D from the Leaves of Glochidion acuminatum MUELL
- Sesquiterpenoids from Artemisia tenuisecta
- Absolute Configuration of Volicitin from the Regurgitant of Lepidopteran Caterpillars and Biological Activity of Volicitin-Related Compounds
- Screening for Tyrosinase Inhibitors among Extracts of Seashore Plants and Identification of Potent Inhibitors from Garcinia subelliptica
- Cytotoxic Screening of Medicinal and Edible Plants in Okinawa, Japan, and Identification of the Main Toxic Constituent of Rhodea japonica (Omoto)(Organic Chemistry)
- Isolation and Antioxidant Activity of Galloyl Flavonol Glycosides from the Seashore Plant, Pemphis acidula
- Phlomisflavosides A and B, New Flavonol Bisglycosides from Phlomis spinidens
- Chemical Constituents of Prangos tschimganica ; Structure Elucidation and Absolute Configuration of Coumarin and Furanocoumarin Derivatives with Anti-HIV Activity
- Farnesyl Hydroxybenzoic Acid Derivatives from Ferula kuhistanica
- Secoiridoid Glycosides from Gentiana olivieri
- Identification of the Antioxidation Reaction Products from a Sinapic Ester in a Lipid Oxidation System
- Antioxidant Mechanism Studies on Ferulic Acid : Isolation and Structure Identification of the Main Antioxidation Product from Methyl Ferulate
- Molecular Cloning, Functional Expression and Characterization of d-Limonene Synthase from Agastache rugosa
- Molecular Cloning, Functional Expression and Characterization of(E)-β-Farnesene Synthase from Citrus junos
- PA41 NEW CYTOTOXIC DITERPENOIDS FROM RABDOSIA LONGITUBA
- Schefflerins A—G, New Triterpene Glucosides from the Leaves of Schefflera arboricola
- Flow Cytometric Estimation of Cytotoxic Activity of Rhodexin A Isolated from Rhodea japonica in Human Leukemia K562 Cells
- Characterization of Ligand Binding Sites on the α_1-Acid Glycoprotein in Humans, Bovines and Dogs
- Myrsinionosides A-E : Megastigmane Glycosides from the Leaves of Myrsine seguinii LEV.
- Tyrosinase Inhibitory Activity of Ethanol Extracts from Medicinal and Edible Plants Cultivated in Okinawa and Identification of a Water-Soluble Inhibitor from the Leaves of Nandina domestica
- Cytotoxic Activity of Maytanprine Isolated from Maytenus diversifolia in Human Leukemia K562 Cells(Toxicology)
- Crotalionosides A—C, Three New Megastigmane Glucosides, Two New Pterocarpan Glucosides and a Chalcone C-Glucoside from the Whole Plants of Crotalaria zanzibarica
- New Sesquiterpene Glucosides from Crepidiastrum lanceolatum
- Three New Taxanes from the Roots of Taxus yunnanensis
- Cytometric Analysis of the Cytotoxic Action of Adenosine 5'-Monophosphate on Rat Thymocytes
- Turpinionosides A-E : Megastigmane Glucosides from Leaves of Turpinia ternata NAKAI
- New Megastigmane and Tetraketide from the Leaves of Euscaphis japonica
- An Iridoid Glucoside Dimer and a Non-glycosidic Iridoid from the Leaves of Lasianthus wallichii
- Labdane Diterpenoids from Marrubium globosum ssp. globosum
- Nepetaracemosides A and B, Iridoid Glucosides from Nepeta racemosa
- Glochidionolactones A-F : Butenolide Glucosides from Leaves of Glochidion zeylanicum (GAERTN) A. JUSS
- A Novel Dimeric Butenolide, Glochidiolide, from the Leaves of Glochidion Acuminatum MUELL
- An Efficient Synthesis of (±)-Hasakol, a Bioactive Coumarin from Citrus hassaku
- Glochiflavanosides A-D : Flavanol Glucosides from the Leaves of Glochidion zeylanicum (GAERTN) A.Juss
- Isolation of Lignan Glucosides and Neolignan Sulfate from the Leaves of Glochidion zeylanicum (Gaertn) A. Juss
- Megastigmane, Benzyl and Phenethyl Alcohol Glycosides, and 4,4'-Dimethoxy-β-truxinic Acid Catalpol Diester from the Leaves of Premna subscandens MERR.
- A Collagen Network Formation Effector from Leaves of Premna subscandens
- Tareciliosides H—M: Further Cycloartane Glycosides from Leaves of Tarenna gracilipes
- Identification of the Antioxidation Reaction Products from a Sinapic Ester in a Lipid Oxidation System
- Tyrosinase Inhibitory Activity of Ethanol Extracts from Medicinal and Edible Plants Cultivated in Okinawa and Identification of a Water-Soluble Inhibitor from the Leaves of Nandina domestica
- Receptor-Mediated Uptake of Human α1-Acid Glycoprotein into Liver Parenchymal Cells in Mice
- Antioxidant Activity of Butane Type Lignans, Secoisolariciresinol, Dihydroguaiaretic Acid, and 7,7'-Oxodihydroguaiaretic Acid
- Syntheses of Secocyclolignanes and Comparative Antioxidative Activity between Secocyclolignane and the Dibenzyl Type of Lignan
- Synthesis and Antioxidant Activity of Olivil-Type Lignans
- Synthesis and Antioxidant Activity of Oxygenated Furofuran Lignans
- Construction of an Expression System for Human α_1-Acid Glycoprotein in E. coli : the Roles of Oligosaccharide Moieties in Structural and Functional Properties
- 5-Alkylresorcinol glucosides from the leaves of Grevillea robusta Allan Cunningham
- Megastigmane glucosides and an unusual monoterpene from the leaves of Cananga odorata var. odorata, and absolute structures of megastigmane glucosides isolated from C. odorata var. odorata and Breynia officinalis
- Elaeocarpionoside, a megastigmane glucoside from the leaves of Elaeocarpus japonicus Sieb. et Zucc.
- Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii
- Myrseguinosides A—E, Five New Glycosides from the Fruits of Myrsine seguinii
- PB103 TOTAL SYNTHESIS OF A TUMOR PROMOTER, TELEOCIDIN B, BY DIRECT INTRODUCTION OF FUNCTIONAL GROUPS ON THE BENZENE PART OF AN INDOLE DERIVATIVE
- Chemical Properties and Enzyme Activity of Termite-nest Material Constructed by the Wood-eating Higher Termite, Nasutitermes takasagoensis
- Effect of the Benzylic Structure of Lignan on Antioxidant Activity
- Syntheses of Secocyclolignanes and Comparative Antioxidative Activity between Secocyclolignane and the Dibenzyl Type of Lignan
- Indole alkaloids from Rheum maximowiczii
- Sesquiterpenoids from Artemisia tenuisecta
- A New Megastigmane Glucoside from Phlomis spinidens
- Gallates of isoorientin and (2S)-1,2-propanediol glucoside from the leaves of Schoepfia jasminodora
- A glycerol α-D-glucuronide and a megastigmane glycoside from the leaves of Guettarda speciosa L.
- Flavonol glycosides from the leaves of Indigofera zollingeriana
- Prenylated flavonoid glucoside and two aliphatic alcohol glycosides from the leaves of Euodia meliaefolia (Hance) Benth
- New Sesquiterpene Glucosides from Crepidiastrum lanceolatum
- A New Phenylpropanoid-Glycerol Conjugate from Helitiera littoralis Dryand
- Three new aliphatic glycosides from the leaves of Antidesma japonicum Sieb. et Zucc.
- Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata
- Eight New Diterpenoids and Two New Nor-Diterpenoids from the Stems of Croton cascarilloides
- Schoepfiajasmins A–H: C-Glycosyl Dihydrochalcones, Dihydrochalcone Glycoside, C-Glucosyl Flavanones, Flavanone Glycoside and Flavone Glycoside from the Branches of Schoepfia jasminodora