Cytotoxic Activity of Maytanprine Isolated from Maytenus diversifolia in Human Leukemia K562 Cells(Toxicology)

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概要

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• We examined the cytotoxic effect of maytanprine isolated from the methanol extract of Maytenus diversifolia on human leukemia K562 cells using a flow cytometer and compared its cytotoxicity with that of maytansine, a potent cytotoxic maytansinoid. Maytanprine at concentrations of 0.03 nM or more (up to 1 nM) attenuated cell growth with decreasing cell viability and increased the population of shrunken cells in a concentration-dependent manner. Complete inhibition of growth by maytanprine was observed at concentrations of 0.3 nM or more. The compound at 0.03 nM markedly decreased the population at G_0G_1 phase in the cell cycle, but only slightly decreased that in the G_2M phase, suggesting the possibility that it inhibits or delays cell division, and increased the population of cells with hypodiploidal DNA (apoptotic cells). The potency of maytanprine in inhibiting cell growth was greater than that of maytansine, although the inhibitory action of maytanprine was similar to that of maytansine. The results suggest that maytanprine exerts a potent inhibitory action on the growth of human leukemia K562 cells. M. diversifolia is one natural source of maytanprine, which is more cytotoxic than maytansine.

• 公益社団法人日本薬学会の論文
• 2004-08-01

著者

• Masuda Tomomi

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co.ltd.

• Masuda T

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Masuda Toshiya

  Laboratory Of Organic Chemistry Faculty Of Agriculture Nagoya University

• Masuda Toshiya

  Laboratories Of Cellular Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences

• Masuda Toshiya

  Faculty Of Human Life Science Osaka City University

• Masuda Toshiya

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Masuda T

  Laboratories Of Cellular Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences

• OYAMA Yasuo

  Laboratories of Cellular Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences

• YONEMORI Shigetomo

  Tropical Biosphere Research Center, University of Ryukyus

• Kanemaru Kaori

  徳島大学 総合科学部生物有機化学

• Kanemaru Kaori

  Laboratories Of Cellular Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences

• Kanemaru Kaori

  Laboratory Of Cellular Signalling Faculty Of Integrated Arts And Sciences The University Of Tokushim

• Oyama Y

  Univ. Tokushima Tokushima Jpn

• Oyama Yasuo

  Laboratory Of Cellular Signalling Faculty Of Integrated Arts And Sciences The University Of Tokushim

• Oyama Yasuo

  Laboratories Of Cellular Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences

• Nakao Hiromi

  Laboratories Of Cell Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences The

• UMEBAYASHI Chisato

  Laboratory of Cell Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima

• SENOKUCHI Kaori

  Laboratories of Cell Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, Th

• Senokuchi Kaori

  Laboratories Of Cell Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences The

• Oyama Y

  Laboratories Of Cell Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences The

• Umebayashi Chisato

  Laboratories Of Cell Signaling And Bioorganic Chemistry Faculty Of Integrated Arts And Sciences The

• Yonemori S

  Tropical Biosphere Res. Center Univ. Of Ryukyus

• Yonemori Shigetomo

  Tropical Bioshere Research Center University Of Ryukyus Japan

• Kanemaru K

  Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima

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