Screening for Tyrosinase Inhibitors among Extracts of Seashore Plants and Identification of Potent Inhibitors from Garcinia subelliptica

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概要

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• The tyrosinase inhibitory activity of methanol extracts of the leaves of 39 plant species growing on the seashore of Iriomote island (Okinawa, Japan) was investigated. The extracts of Hibiscus tiliaceus, Carex pumila, and Garcinia subelliptica showed potent activity among them. The inhibitors in the extract of Garcinia subelliptica were purified by assay-guided fractionation to give two biflavonoids. These were known compounds (2R,3S-5,7,4′,5″,7″,3′′′,4′′′-heptahydroxy flavanone[3-8″] flavone and 5,7,4′,5″,7″,3′′′,4′′′-heptahydroxy[3-8″] biflavanone), although their strong inhibitory activity toward tyrosinase is revealed for the first time in this work. One of these biflavonoids (2R,3S-5,7,4′,5″,7″,3′′′,4′′′-heptahydroxy flavanone[3-8″] flavone) showed much stronger activity (IC50 2.5 μM) than that of kojic acid (IC50 9.1 μM) when L-tyrosine was used as the substrate.

• 社団法人 日本農芸化学会の論文
• 2005-01-23

著者

• 高石 喜久

  徳島大院薬

• Masuda Tomomi

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co.ltd.

• Takeda Yoshio

  Faculty of Pharmacy, Yasuda Womens University

• Takeda Y

  Fac. Of Integrated Arts And Sciences Univ. Of Tokushima

• Takeda Y

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Masuda T

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Masuda Toshiya

  Faculty Of Integrated Arts And Sciences University Of Tokushima

• Masuda Toshiya

  Faculty Of Human Life Science Osaka City University

• Masuda Toshiya

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• YAMASHITA Daiki

  Faculty of Integrated Arts and Sciences, University of Tokushima

• YONEMORI Shigetomo

  Tropical Biosphere Research Center, University of Ryukyus

• Takeda Yoshio

  Faculty Of General Arts And Sciences The Tokushima University

• Yamashita Daiki

  Faculty Of Integrated Arts And Sciences University Of Tokushima

• Yonemori S

  Tropical Biosphere Res. Center Univ. Of Ryukyus

• Yonemori Shigetomo

  Tropical Bioshere Research Center University Of Ryukyus Japan

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