P-25 Chloranthus spicatusの成分研究(ポスター発表の部)
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概要
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We have been studying on the ethnological herbal medicines used by ethnic minority groups in Yunnan Province, China, aimed at searching new natural products leads for therapeutic agents. As a part of this study, we have investigated on the roots of C. spicatus collected in Yunnan Province, which have been used by the Dai ethnic group for the treatment of high-blood pressure in combination with several herbal plants. Two new and a known compounds were isolated from the EtOAc-soluble fraction from the roots of C. spicatus. The structures for these compounds were characterized by the 1D- and 2D-NMR examinations and their absolute sterostructures were elucidated by CD spectroscopic analysis. These compounds are dimeric lindenane-type sesquiterpenes, in which two lindenane units are bonded at C-6-C-8' and C-15-C-9' by endo Dields-Alder cycloaddition, with a unique 18-membered macrocyclic trilactone ring. We have also studied on the C. spicatus roots, cultivated in Japan, which has resulted in the isolation of four new dimeric lindenane-sesquiterpene with an 18-membered macrocyclic trilactone ring, a new dimeric lindenane-sesquiterpene with an acetyl group, and a new indenane sesquiterne, together with four known dimeric lindenane-sesquiterpenes. The structures for these new compounds were also elucidate by detailed spectroscopic examinations. Among the isolated compounds, two compounds, isolated from the roots of C. spicatus cultivated in Japan, contained a perhydroxide group in the molecular. They are the first examples of dimeric lindenane-sesquiterpenes possessing a perhydroxide group.
- 2008-09-01
著者
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高石 喜久
徳島大院薬
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山下 貴司
浜松ホトニクス(株)中央研究所
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山下 貴司
浜松ホトニクス・中央研
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柏田 良樹
徳島大学薬学部
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村上 光太郎
崇城大薬
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孫 漢董
中国科学院昆明植物研究所
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孫 漢董
中国科学院昆明植物研
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金 尚永
徳島大院薬
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川添 和義
徳島大病院薬
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柏田 良樹
徳島大院薬
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李 順林
中国科学院昆明植物研
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柏田 良樹
徳島大学大学院ヘルスバイオサイエンス研究部(薬学系)
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柏田 良樹
Faculty Of Pharmaceutical Sciences Kyushu Unversity
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Kashiwada Y
Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn
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Kashiwada Yoshiki
Niigata College Of Pharmacy
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山下 貴司
浜松ホトニクス(株) 中央研究所
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