Antitumor Agents. 169. Dysoxylum cumingianum. V. Cumingianosides P and Q, New Cytotoxic Triterpene Glucosides with an Apotirucallane-Type Skeleton from Dysoxylum cumingianum

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概要

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• Detailed chemical studies on the cytotoxic fraction from the leaves of Dysoxylum cumingianum have resulted in the isolation of two new triterpene glucosides, cumingianosides P (18) and Q (19), with an apotirucallane-type skeleton. The structures of 18 and 19 were determined by spectral examinations, and by conversion of cumingianosides C (3) and A (1) into 18 and 19,respectively. The cytotoxicities of cumingianosides P and Q against over 50 human cancer cell lines were evaluated. Cumingianoside P exhibited significant (EC_<50> <4 μM) cytotoxicity against 37 human cancer cell lines. Among them, the UO-31 (renal cancer) cell line was the most sensitive to this compound (EC_<50> 0.267 μM). In contrast, cumingianoside Q showed selective cytotoxicity against NCI-H522 (non-small cell lung cancer) cells with an EC_<50> value of 1.67 μM, and exhibited no cytotoxicity (EC_<50> >10 μM) against most of the remaining cancer cell lines.

• 公益社団法人日本薬学会の論文
• 1997-01-15

著者

• 柏田 良樹

  徳島大学薬学部

• Lee K‐h

  Division Of Medicinal Chemistry And Natural Products School Of Pharmacy University Of North Carolina

• Lee K‐h

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Lee Kuo-hsiung

  Natural Products Research Laboratories School Of Pharmacy University Of North Carolina

• Lee Kuo-hsiung

  Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy

• FUJIOKA Toshihiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• CHEN Ih-Sheng

  School of Pharmacy, Kaohsiung Medical College

• Chen I‐s

  Kaohsiung Medical Univ. Kaohsiung Twn

• Chen Ih-sheng

  Natural Products Research Center Kaoshiung Medical College

• MIHASHI Kunihide

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 柏田 良樹

  徳島大院薬

• 柏田 良樹

  徳島大学大学院ヘルスバイオサイエンス研究部(薬学系)

• Sakurai Akio

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 柏田 良樹

  Faculty Of Pharmaceutical Sciences Kyushu Unversity

• Kashiwada Y

  Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn

• Kashiwada Yoshiki

  Niigata College Of Pharmacy

• Lee K‐h

  Univ. North Carolina Nc Usa

• Fujioka T

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Fujioka Toshihiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Mihashi Kunihide

  Faculty Of Pharmaceutical Sciences Fukuoka University

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