58 桂皮ジテルペンの化学的研究

概要

論文の詳細を見る
Recently, Koda et al. have reported that the water extractives of Cinnamomi Cortex (the dried bark of Cinnamomum cassia Blume) exhibit potent anti-complement activity. For the purpose of identification of the substance(s) possessing this activity, we had isolated a series of diterpenes (compds. I-XIII) from the fraction exhibiting anti-complement activity of the water extractives and elucidated their structures. These diterpenes so far obtained from C. Cortex are classified into the three groups, namely those of ketal-, lactone- and diketone-type. In a continuation of this work, additional five kinds of diterpenes (compds. 1-5) have been characterized, which are closely related to each other in structure and belong to a new group different from the above three groups. They are novel pentacyclic diterpenes with a new skeleton consisting of two six-membered rings and three five-membered rings. As for pharmacological test of anti-complement activity for each diterpene (compds. I-XIII and 1-5) isolated from C. Cortex, it will be discussed in near future.
天然有機化合物討論会の論文
1980-09-10