Synthesis and Anti-HIV Activity of 3-Alkylamido-3-deoxy-betulinic Acid Derivatives
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概要
- 論文の詳細を見る
3-Alkylamido-3-deoxy-betulinic acids were synthesized and evaluated for anti-HIV activity as part of the structure-activity relationship study of the potent anti-HIV agent 3-O-(3', 3'-dimethyl)-succinyl-betulinic acid (DSB) (2). 3α-Diglycorylamide-3-deoxy-betulinic acid demonstrated relatively potent anti-HIV activity (EC_<50>0.24 μM, TI 728). However, replacing the ester group at C-3 in 2 and its analogues with an amido group yielded inactive or much less potent compounds against HIV replication, indicating that the ester group at C-3 in 2-4 is essential for potent anti-HIV activity.
- 公益社団法人日本薬学会の論文
- 2000-09-01
著者
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柏田 良樹
徳島大学薬学部
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Lee Kuo-hsiung
Natural Products Research Laboratories School Of Pharmacy University Of North Carolina
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Lee Kuo-hsiung
Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy
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Lee Kuo-hsiung
Natural Products Laboratory School Of Pharmacy University Of North Carolina
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OKABE Hikaru
Faculty of Pharmaceutical Sciences, Fukuoka University
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NAGAO Tsuneatsu
Faculty of Pharmaceutical Sciences, Fukuoka University
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Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
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MORRIS-NATSCHKE Susan
Natural Products Research Laboratories, School of Pharmacy, University of North Carolina
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柏田 良樹
徳島大院薬
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柏田 良樹
徳島大学大学院ヘルスバイオサイエンス研究部(薬学系)
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柏田 良樹
Faculty Of Pharmaceutical Sciences Kyushu Unversity
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Kashiwada Y
Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn
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Kashiwada Yoshiki
Niigata College Of Pharmacy
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CHIYO Junko
Niigata College of Pharmacy
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IKESHIRO Yasumasa
Niigata College of Pharmacy
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COSENTINO L.
BBI-Biotech Research Laboratories
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FOWKE Keith
BBI-Biotech Research Laboratories
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Nagao Tsuneatsu
Faculty Of Pharmaceutical Sciences Fukuoka University
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Morris-natschke Susan
Natural Products Laboratory School Of Pharmacy University Of North Carolina
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