Structural Elucidation and Chemical Conversion of Amorphispironone, a Novel Spironone form Amorpha fruticosa, to Rotenoids
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概要
- 論文の詳細を見る
To search for possible antiumor promoters, we carried out an investigation of the leaves of Amorpha fruticosa L. (Leguminosae). The novel spironone type rotenoid, amorphispironone (1), isolated together with four known rotenoids, tephrosin (2), amorphigenin (3), 12a-hydroxyamorphigenin (4) and 12a-hydroxydalpanol (5). Some of these compounds were inhibitors of Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate. The structure of 1 was derermined from 2D-NMR spectral data and difference NOE experiments.Amorphispironone (1) was also converted to know rotenoids in order to confirm the proposed structure.
- 社団法人日本薬学会の論文
- 1993-01-15
著者
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伊藤 一男
Faculty of Pharmacy, Meijo University
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伊藤 一男
名城大学薬学部
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Lee K‐h
Division Of Medicinal Chemistry And Natural Products School Of Pharmacy University Of North Carolina
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Lee K‐h
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Lee Kuo-hsiung
Natural Products Research Laboratories School Of Pharmacy University Of North Carolina
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Lee Kuo-hsiung
Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy
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木島 孝夫
Kyoto Pharmaceutical University
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小塚 睦夫
Kyoto Pharmaceutical University
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春名 光昌
Faculty of Pharmacy, Meijo University
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ESTES James
Department of Botany, The University of Oklahoma at Norman
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春名 光昌
名城大・薬
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寺田 裕樹
Kyoto Pharmaceutical University
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國米 みどり
Kyoto Pharmaceutical University
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Li Leping
Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy
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Wang Hui-kang
Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy
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Estes James
Department Of Botany The University Of Oklahoma At Norman
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木島 孝夫
京都薬科大学
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Lee K‐h
Univ. North Carolina Nc Usa
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伊藤 一男
Faculty Of Pharmacy Meijo University
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小塚 睦夫
Kyoto Pharmaceutical Univ. Kyoto Jpn
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