Total Synthesis of (±)-Silybin, an Antihepatotoxic Flavonolignan
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概要
- 論文の詳細を見る
The flavonolignan (±)-silybin (1), having an antihepatotoxic activity, has been synthesized via a key intermediate (9), which was prepared from readily available starting materials (2) and (3). The aldehyde (9) was transformed to the methoxymethyl ether (10), which was condensed with an acetophenone derivative (11) to yield the chalcone (12). Oxidation of the chalcone (12) with alkaline hydrogen peroxide, followed by treatment of the resulting epoxide (13) with hydrochloric acid afforded (±)-1.
- 社団法人日本薬学会の論文
- 1985-04-25
著者
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田中 斉
Faculty Of Pharmacy Meijo University
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伊藤 一男
Faculty of Pharmacy, Meijo University
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柴田 正芳
Research Division, Taiyo Pharmaceutical Industry Co., Ltd.
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大平 一夫
Research Division, Taiyo Pharmaceutical Industry Co., Ltd.
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大平 一夫
Research Division Taiyo Pharmaceutical Industry Co. Ltd.
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柴田 正芳
Research Division Taiyo Pharmaceutical Industry Co. Ltd.
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伊藤 一男
Faculty Of Pharmacy Meijo University
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