2 Lindera属植物3種の新奇フラボノイド類の単離と構造(ポスター発表の部)

概要

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Four new flavonoids linderatin (1), linderatone (2), methyllinderatone (3), and isolinderatone (4) were isolated from the leaves of L. umbellata var. lancea, L. umbellata, and L. umbellata var. membranacea, and their structures were established by chemical and spectroscopic means. The structure of linderatin (1) was determined by direct comparison with the product which was synthesized by condensation of 2',4',6'-trihydroxydihydrochalcone (6) and piperitol (18). Hydrogenolysis of linderatone (2) with Raney Ni gave linderatin (1) and methylation of linderatone (2) with CH_2N_2 afforded methyllinderatone (3). Therefore, the structures of linderatone and methyllinderatone were represented by the formula 2 and 3, respectively. Finally, isolinderatone was transformed into the dihydrochalcone derivative (15) which was identical with the product derived from rubranine (16) with known stereostructure. Thus, the structure of isolinderatone was established to be 4. These new compounds discussed above were very curious products in which a flavonoid unit is linked with a cyclic monoterpene.
天然有機化合物討論会の論文
1988-09-26