Constituents of Rosaceous Plants. I. Structures of New Triterpenoids from Cowania mexicana
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概要
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In our search for possible anti-tumor-promoters, we carried out an investigation of the leaves and branches of Cowania mexicana D. DON (Rosaceae). Two new cucurbitane type triterpenes, 15-oxo-cucurbitacin F (3) and 15-oxo-23,24-dihydrocucurbitacin F (4), were isolated together with cucurbitacin F (1) and 23,24-dihydrocucurbitacin F (2). These triterpenes were inhibitors of Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate, a well-known tumor-promoter. The structures of 3 and 4 were determined from 2D-NMR spectral data and difference NOE experiments.
- 社団法人日本薬学会の論文
- 1993-09-15
著者
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伊藤 一男
Faculty of Pharmacy, Meijo University
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伊藤 一男
名城大学薬学部
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Lee K‐h
Division Of Medicinal Chemistry And Natural Products School Of Pharmacy University Of North Carolina
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Lee K‐h
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Lee Kuo-hsiung
Natural Products Research Laboratories School Of Pharmacy University Of North Carolina
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Lee Kuo-hsiung
Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy
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木島 孝夫
Kyoto Pharmaceutical University
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高崎 みどり
Kyoto Pharmaceutical University
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小塚 睦夫
Kyoto Pharmaceutical University
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春名 光昌
Faculty of Pharmacy, Meijo University
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ESTES James
Department of Botany, The University of Oklahoma at Norman
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春名 光昌
名城大・薬
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Estes James
Department Of Botany The University Of Oklahoma At Norman
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真岡 孝至
Kyoto Pharmaceutical University
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Lee K‐h
Univ. North Carolina Nc Usa
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伊藤 一男
Faculty Of Pharmacy Meijo University
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Maoka T
Sun Biorex Co. Ltd. Kyoto Jpn
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小塚 睦夫
Kyoto Pharmaceutical Univ. Kyoto Jpn
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