Synthesis and Antiplatelet, Antiinflammatory and Antiallergic Activities of 2,3-Disubstituted 1,4-Naphthoquinones

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概要

• 論文の詳細を見る

• Modification of 2-acetamido-3-chloro-1,4-naphthoquinone, which has potent antiplatelet, antiallergic and antiinflammatory activities, led to a series of 2,3-disubstituted 1,4-naphthoquinones. Some of these compounds showed significant antiplatelet, antiallergic and antiinflammatory activities. Among them, 2-methoxy-3-chloro-1,4-naphthoquinone (15) and 2-ethoxy-3-chloro-1,4-naphthouinone (17) exhibited potent inhibitory effects on neutrophil and mast cell degranulation. 2-Methoxy-1,4-naphthoquinone (20) and 2-ethoxy-1,4-naphthoquinone (21) exhibited potent inhibitory effect on neutrophil superoxide formation. These four compounds were thus selected for further evaluation.

• 社団法人日本薬学会の論文
• 1996-06-15

著者

• HUANG Li-Jiau

  Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University

• KUO Sheng-Chu

  Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University

• Lee Kuo-hsiung

  Natural Products Research Laboratories School Of Pharmacy University Of North Carolina

• Lee Kuo-hsiung

  Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy

• Tzeng C‐c

  Kaohsiung Medical Univ. Kaohsiung City Twn

• Teng C‐m

  National Taiwan Univ. Taipei Twn

• Teng Che-ming

  Pharmacological Institute College Of Medicine National Taiwan University

• Huang L‐j

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Huang Li-jiau

  Graduate Institute Of Pharmaceutical Chemistry College Of Pharmacy China Medical University

• Kuo S‐c

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Kuo Sheng-chu

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Lee Kuo-hsiung

  Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products Shool Of Pharmacy U

• LIEN Jin-Cherng

  Graduate Institute of Pharmaceutical Chemistry, China Medical College

• WANG Jih-Pyang

  Department of Medical Research, Taichung Veterans General Hospital

• Lien Jin-cherng

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Wang J‐p

  Department Of Education And Research Taichung Veterans General Hospital

• Wang Jih-pyang

  Department Of Education And Research Taichung Veterans General Hospital

• Huang Li-Jiau

  Graduate Institute of Pharmaceutical Chemistry China Medical College

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